Novel Zn(II) complexes with non-steroidal anti-inflammatory ligand, flufenamic acid: Characterization, topoisomerase I inhibition activity, DNA and HSA binding studies
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F17%3A10370129" target="_blank" >RIV/00216208:11310/17:10370129 - isvavai.cz</a>
Výsledek na webu
<a href="https://doi.org/10.1016/j.jinorgbio.2017.09.005" target="_blank" >https://doi.org/10.1016/j.jinorgbio.2017.09.005</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.jinorgbio.2017.09.005" target="_blank" >10.1016/j.jinorgbio.2017.09.005</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Novel Zn(II) complexes with non-steroidal anti-inflammatory ligand, flufenamic acid: Characterization, topoisomerase I inhibition activity, DNA and HSA binding studies
Popis výsledku v původním jazyce
A series of new Zn(II) complexes with flufenamic acid (flu) has been synthesized, namely [Zn3(drnso)2(flu)61 (1), [Zn-3(flu)(6)(py)(2)] (2), (Zn(flu)(2)(tnien)] (3), [ZnCl(fiu)(neo)] (4), and [Zn(cyciam)(flu)(2)] (5), where py = pyridine, tmen = N,N,N',N'-Tetramethylethylene diamine, neo = 2,9-Dimethyl-1,10-phenanthroline and cyclam = 1,4,8,11-Tetraazacyclotetradecane. These complexes have been characterized by infrared spectroscopy, single-crystal X-ray structure analysis, elemental and thermal analysis. All complexes contain deprotonated flufenamic acid coordinated via carboxylato group to zinc atoms, but their structures differ in the carboxylato binding mode, the coordination number of the central atom, the shape of the coordination polyhedra and the resultant supramolecular structures. Furthermore, an interaction of complexes with calf-thymus DNA (CT DNA) and human serum albumin (HSA) has been investigated by spectroscopic techniques. Moreover, the complexes 1 and 2 inhibit the catalytic activity of topoisomerase I at 60 mu M.
Název v anglickém jazyce
Novel Zn(II) complexes with non-steroidal anti-inflammatory ligand, flufenamic acid: Characterization, topoisomerase I inhibition activity, DNA and HSA binding studies
Popis výsledku anglicky
A series of new Zn(II) complexes with flufenamic acid (flu) has been synthesized, namely [Zn3(drnso)2(flu)61 (1), [Zn-3(flu)(6)(py)(2)] (2), (Zn(flu)(2)(tnien)] (3), [ZnCl(fiu)(neo)] (4), and [Zn(cyciam)(flu)(2)] (5), where py = pyridine, tmen = N,N,N',N'-Tetramethylethylene diamine, neo = 2,9-Dimethyl-1,10-phenanthroline and cyclam = 1,4,8,11-Tetraazacyclotetradecane. These complexes have been characterized by infrared spectroscopy, single-crystal X-ray structure analysis, elemental and thermal analysis. All complexes contain deprotonated flufenamic acid coordinated via carboxylato group to zinc atoms, but their structures differ in the carboxylato binding mode, the coordination number of the central atom, the shape of the coordination polyhedra and the resultant supramolecular structures. Furthermore, an interaction of complexes with calf-thymus DNA (CT DNA) and human serum albumin (HSA) has been investigated by spectroscopic techniques. Moreover, the complexes 1 and 2 inhibit the catalytic activity of topoisomerase I at 60 mu M.
Klasifikace
Druh
J<sub>imp</sub> - Článek v periodiku v databázi Web of Science
CEP obor
—
OECD FORD obor
10402 - Inorganic and nuclear chemistry
Návaznosti výsledku
Projekt
—
Návaznosti
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Ostatní
Rok uplatnění
2017
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
Journal of Inorganic Biochemistry
ISSN
0162-0134
e-ISSN
—
Svazek periodika
177
Číslo periodika v rámci svazku
December
Stát vydavatele periodika
US - Spojené státy americké
Počet stran výsledku
16
Strana od-do
143-158
Kód UT WoS článku
000419812400016
EID výsledku v databázi Scopus
2-s2.0-85029920077