Lanthanide(III) complexes of monophosphinate/monophosphonate DOTA-analogues: Effects of the substituents on the formation rate and radiolabelling yield

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F18%3A10381829" target="_blank" >RIV/00216208:11310/18:10381829 - isvavai.cz</a>

Výsledek na webu

<a href="https://doi.org/10.1039/c8dt02608d" target="_blank" >https://doi.org/10.1039/c8dt02608d</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1039/c8dt02608d" target="_blank" >10.1039/c8dt02608d</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Lanthanide(III) complexes of monophosphinate/monophosphonate DOTA-analogues: Effects of the substituents on the formation rate and radiolabelling yield

Popis výsledku v původním jazyce

H4dota and its analogues are routinely used for complexation of lanthanide radioisotopes in nuclear medicine. Many of the radioisotopes have short half-lives and, thus, the complexation rate plays an important role. Notwithstanding that, the relationship between ligand structures and complexation rates is not well understood. Here we report a complexation study of H(4)dota and its analogues bearing one phosphonate or phosphinate pendant arm. The substituents on the phosphinate group were non-coordinating (-H) or contained another coordinating group (-CH2N(CH2COOH)(2), -CH2PO2H2 or -CH2NH2). The basicity of ligands, stability of reaction intermediates, formation rates of Ce-III complexes, and Lu-177(III) radiolabelling were studied. The complexation rates and labelling yields do not show any correlation with ligand basicity. In contrast, the additional chelating group attached to the pendant arm plays an important role. A decreased complexation rate and lower labelling yield were found for compounds bearing an additional amino group, whereas improved properties were found for the compound bearing a geminal bis(phosphinate) pendant arm. It indicates that the introduction of chelating pendant arms with acidic coordinating groups might be a promising strategy to improve radiolabelling of macrocyclic carriers with metal radioisotopes.

Název v anglickém jazyce

Lanthanide(III) complexes of monophosphinate/monophosphonate DOTA-analogues: Effects of the substituents on the formation rate and radiolabelling yield

Popis výsledku anglicky

H4dota and its analogues are routinely used for complexation of lanthanide radioisotopes in nuclear medicine. Many of the radioisotopes have short half-lives and, thus, the complexation rate plays an important role. Notwithstanding that, the relationship between ligand structures and complexation rates is not well understood. Here we report a complexation study of H(4)dota and its analogues bearing one phosphonate or phosphinate pendant arm. The substituents on the phosphinate group were non-coordinating (-H) or contained another coordinating group (-CH2N(CH2COOH)(2), -CH2PO2H2 or -CH2NH2). The basicity of ligands, stability of reaction intermediates, formation rates of Ce-III complexes, and Lu-177(III) radiolabelling were studied. The complexation rates and labelling yields do not show any correlation with ligand basicity. In contrast, the additional chelating group attached to the pendant arm plays an important role. A decreased complexation rate and lower labelling yield were found for compounds bearing an additional amino group, whereas improved properties were found for the compound bearing a geminal bis(phosphinate) pendant arm. It indicates that the introduction of chelating pendant arms with acidic coordinating groups might be a promising strategy to improve radiolabelling of macrocyclic carriers with metal radioisotopes.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10402 - Inorganic and nuclear chemistry

Projekt

<a href="/cs/project/LTC17067" target="_blank" >LTC17067: Využití NMR relaxačních a difúzních měření pro stanovení dynamiky komplexních molekulárních systémů</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2018

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Dalton Transactions

ISSN

1477-9226

e-ISSN

—

Svazek periodika

47

Číslo periodika v rámci svazku

37

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

10

Strana od-do

13006-13015

Kód UT WoS článku

000445637000025

EID výsledku v databázi Scopus

2-s2.0-85054388740