Adamantane-1-carboxamides: Synthesis and antimicrobial activity

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F18%3A10457687" target="_blank" >RIV/00216208:11310/18:10457687 - isvavai.cz</a>

Výsledek na webu

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=-sMY5Y4hWB" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=-sMY5Y4hWB</a>

DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Adamantane-1-carboxamides: Synthesis and antimicrobial activity

Popis výsledku v původním jazyce

The rapid emergence of resistant bacteria highlights the urgent demand for new effective drugs. In view of the importance of adamantane skeleton in various antimicrobial drugs, herein the synthesis of N-adamantane-1-carboxamides of polyamine derivatives is described. The in vitro antibacterial activity of the new synthesized compounds against two Gram-positive (Staphylococcus aureus, Bacillus subtilis) and two Gram-negative (Escherichia coli, Pseudomonas aeruginosa) bacteria, as well as the antifungal activity against Candida albicans was assessed. The results revealed that amongst the new synthesized bisamides, N,N&apos;-bis-adamantane-1-carboxamide of 1,6-diaminohexane was the most effective one and inhibited both Gram-negative and Gram-positive strains with MIC of 125 μg.ml(-1). Moreover, the same amide showed the highest antifungal activity (MIC of 63 μg.ml(-1)) against Candida albicans.

Název v anglickém jazyce

Adamantane-1-carboxamides: Synthesis and antimicrobial activity

Popis výsledku anglicky

The rapid emergence of resistant bacteria highlights the urgent demand for new effective drugs. In view of the importance of adamantane skeleton in various antimicrobial drugs, herein the synthesis of N-adamantane-1-carboxamides of polyamine derivatives is described. The in vitro antibacterial activity of the new synthesized compounds against two Gram-positive (Staphylococcus aureus, Bacillus subtilis) and two Gram-negative (Escherichia coli, Pseudomonas aeruginosa) bacteria, as well as the antifungal activity against Candida albicans was assessed. The results revealed that amongst the new synthesized bisamides, N,N&apos;-bis-adamantane-1-carboxamide of 1,6-diaminohexane was the most effective one and inhibited both Gram-negative and Gram-positive strains with MIC of 125 μg.ml(-1). Moreover, the same amide showed the highest antifungal activity (MIC of 63 μg.ml(-1)) against Candida albicans.

Druh

J_SC - Článek v periodiku v databázi SCOPUS

CEP obor

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OECD FORD obor

10401 - Organic chemistry

Projekt

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Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2018

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Bulgarian Chemical Communications

ISSN

0861-9808

e-ISSN

2534-9899

Svazek periodika

50

Číslo periodika v rámci svazku

Special issue B

Stát vydavatele periodika

BG - Bulharská republika

Počet stran výsledku

6

Strana od-do

49-54

Kód UT WoS článku

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EID výsledku v databázi Scopus

2-s2.0-85054732050