Understanding the Fragmentation Pathways of Carbocyclic Derivatives of Amino Acids by Using Electrospray Ionization Tandem Mass Spectrometry

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F19%3A10399572" target="_blank" >RIV/00216208:11310/19:10399572 - isvavai.cz</a>

Výsledek na webu

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=t-5QmNj4Ma" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=t-5QmNj4Ma</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1080/00032719.2019.1593431" target="_blank" >10.1080/00032719.2019.1593431</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Understanding the Fragmentation Pathways of Carbocyclic Derivatives of Amino Acids by Using Electrospray Ionization Tandem Mass Spectrometry

Popis výsledku v původním jazyce

Aminoacyl derivatives of aminoadamantanes amantadine and rimantadine have been investigated in regard to their antiviral properties. So far, few studies on the mass spectrometric fragmentation pathway of these compounds have been reported using high-resolution mass spectrometry (HRMS). Two major fragmentation pathways have been observed. For the rimantadine derivatives, losses of rimantadine and N-(1-adamantyl) ethylformamide were described. Similarly, in case of amantadine derivatives, there were losses of amantadine and N-(1-adamantyl) formamide. The loss of the aminoacyl group was common to all of the studied compounds. Understanding the fragmentation mechanism can bring new insight into the characterization of these compounds.

Název v anglickém jazyce

Understanding the Fragmentation Pathways of Carbocyclic Derivatives of Amino Acids by Using Electrospray Ionization Tandem Mass Spectrometry

Popis výsledku anglicky

Aminoacyl derivatives of aminoadamantanes amantadine and rimantadine have been investigated in regard to their antiviral properties. So far, few studies on the mass spectrometric fragmentation pathway of these compounds have been reported using high-resolution mass spectrometry (HRMS). Two major fragmentation pathways have been observed. For the rimantadine derivatives, losses of rimantadine and N-(1-adamantyl) ethylformamide were described. Similarly, in case of amantadine derivatives, there were losses of amantadine and N-(1-adamantyl) formamide. The loss of the aminoacyl group was common to all of the studied compounds. Understanding the fragmentation mechanism can bring new insight into the characterization of these compounds.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10406 - Analytical chemistry

Projekt

—

Návaznosti

S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2019

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Analytical Letters

ISSN

0003-2719

e-ISSN

—

Svazek periodika

52

Číslo periodika v rámci svazku

13

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

8

Strana od-do

2069-2076

Kód UT WoS článku

000466010300001

EID výsledku v databázi Scopus

2-s2.0-85063901632