Biological activity of two novel zinc(II) complexes with NSAID mefenamic acid

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F20%3A10410667" target="_blank" >RIV/00216208:11310/20:10410667 - isvavai.cz</a>

Výsledek na webu

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=JFt.nHjBX9" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=JFt.nHjBX9</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s11696-019-01003-5" target="_blank" >10.1007/s11696-019-01003-5</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Biological activity of two novel zinc(II) complexes with NSAID mefenamic acid

Popis výsledku v původním jazyce

Zinc(II) mefenamate [Zn(mef)(2)] (1) along with two novel Zn(II) crystalline complexes with Hmef (mefenamic acid) [Zn(dmso)(2)(mef)(2)] (2) and [Zn(cyclam)(mef)(2)] (3) were synthesized and characterized by infrared spectroscopy, elemental and thermal analysis. Crystal structures of complexes 2 and 3 were determined by single-crystal X-ray structure analysis. The biological activity of complexes was investigated using various methods. First, the ability of the complexes to scavenge radicals [2,2-diphenyl-1-picrylhydrazyl-DPPH and diammonium 2,2 &apos;-Azino-bis(3-ethylbenzothiazoline-6-sulfonate)-ABTS] was investigated, indicating selective scavenging activity of studied compounds for ABTS(center dot+) in comparison to DPPH center dot. The complexes 2 and 3 are more active than the free Hmef. Second, the interaction of the complexes with serum albumins was investigated and obtained binding constants are within optimal range for transport in bloodstream. Third, the interaction of complexes with fish sperm DNA (FS-DNA) was studied by UV-Vis titration and competitive binding studies with ethidium bromide (EB). The obtained values of binding constants calculated from UV-Vis measurements and fluorescence measurements, respectively, indicates the strongest binding for complex 3. Fourth, antimicrobial activity of compounds 1-3 was studied against bacteria (S. aureus and E. coli), yeast (C. parapsilosis) and filamentous fungi (R. oryzae, A. alternata, M. gypseum); complex 1 indicates highest activity against filamentous fungi R. oryzae and A. alternate whereas complex 2 displays highest antimicrobial activity against both Gram-positive and Gram-negative bacteria and yeast.

Název v anglickém jazyce

Biological activity of two novel zinc(II) complexes with NSAID mefenamic acid

Popis výsledku anglicky

Zinc(II) mefenamate [Zn(mef)(2)] (1) along with two novel Zn(II) crystalline complexes with Hmef (mefenamic acid) [Zn(dmso)(2)(mef)(2)] (2) and [Zn(cyclam)(mef)(2)] (3) were synthesized and characterized by infrared spectroscopy, elemental and thermal analysis. Crystal structures of complexes 2 and 3 were determined by single-crystal X-ray structure analysis. The biological activity of complexes was investigated using various methods. First, the ability of the complexes to scavenge radicals [2,2-diphenyl-1-picrylhydrazyl-DPPH and diammonium 2,2 &apos;-Azino-bis(3-ethylbenzothiazoline-6-sulfonate)-ABTS] was investigated, indicating selective scavenging activity of studied compounds for ABTS(center dot+) in comparison to DPPH center dot. The complexes 2 and 3 are more active than the free Hmef. Second, the interaction of the complexes with serum albumins was investigated and obtained binding constants are within optimal range for transport in bloodstream. Third, the interaction of complexes with fish sperm DNA (FS-DNA) was studied by UV-Vis titration and competitive binding studies with ethidium bromide (EB). The obtained values of binding constants calculated from UV-Vis measurements and fluorescence measurements, respectively, indicates the strongest binding for complex 3. Fourth, antimicrobial activity of compounds 1-3 was studied against bacteria (S. aureus and E. coli), yeast (C. parapsilosis) and filamentous fungi (R. oryzae, A. alternata, M. gypseum); complex 1 indicates highest activity against filamentous fungi R. oryzae and A. alternate whereas complex 2 displays highest antimicrobial activity against both Gram-positive and Gram-negative bacteria and yeast.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10402 - Inorganic and nuclear chemistry

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2020

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Chemical Papers

ISSN

2585-7290

e-ISSN

—

Svazek periodika

74

Číslo periodika v rámci svazku

5

Stát vydavatele periodika

SK - Slovenská republika

Počet stran výsledku

16

Strana od-do

1525-1540

Kód UT WoS článku

000520851600016

EID výsledku v databázi Scopus

2-s2.0-85076209179