Voltammetric study of triazole antifungal agent terconazole on sp(3) and sp(2) carbon-based electrode materials

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F20%3A10410708" target="_blank" >RIV/00216208:11310/20:10410708 - isvavai.cz</a>

Výsledek na webu

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=uz3niTJ~FR" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=uz3niTJ~FR</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.jelechem.2020.114054" target="_blank" >10.1016/j.jelechem.2020.114054</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Voltammetric study of triazole antifungal agent terconazole on sp(3) and sp(2) carbon-based electrode materials

Popis výsledku v původním jazyce

Terconazole belongs to synthetic triazole antifungal agents, inhibiting biosynthesis of ergosterol or other sterols and thus disrupting cell wall synthesis in fungi. In this study, electrochemical behavior of terconazole was studied for the first time using cyclic voltammetry and differential pulse voltammetry on boron doped diamond electrode (BDD) with different surface treatments leading to O-terminated, H-terminated and polished surfaces, as well as on glassy carbon (GCE) and basal-plane pyrolytic graphite electrodes (PGE). Terconazole is not reducible within the potential window on these electrode materials. It is oxidizable in aqueous solutions in pH range from 2.0 to 12.0 in two steps due to the presence of piperazine ring in itsmolecule, possessing two redox centers at the tertiary nitrogen atoms, by an ECE mechanism. Optimal conditions were found for determination of terconazole in 0.1 mol L-1 phosphate buffer pH 7.2. Using differential pulse voltammetry, the lowest detection limit of 0.40 mu mol L-1 and excellent repeatability (RSD 1.1%) were achieved on O-terminated BDD when in-situ anodic activation was used prior to each scan. This is beneficial in comparison with GCE and PGE; their necessity of ex-situ polishing worsens the signal repeatability (RSD similar to 4%) and detection limits reaching 0.50 mu mol L-1 and 1.23 mu mol L-1, respectively.

Název v anglickém jazyce

Voltammetric study of triazole antifungal agent terconazole on sp(3) and sp(2) carbon-based electrode materials

Popis výsledku anglicky

Terconazole belongs to synthetic triazole antifungal agents, inhibiting biosynthesis of ergosterol or other sterols and thus disrupting cell wall synthesis in fungi. In this study, electrochemical behavior of terconazole was studied for the first time using cyclic voltammetry and differential pulse voltammetry on boron doped diamond electrode (BDD) with different surface treatments leading to O-terminated, H-terminated and polished surfaces, as well as on glassy carbon (GCE) and basal-plane pyrolytic graphite electrodes (PGE). Terconazole is not reducible within the potential window on these electrode materials. It is oxidizable in aqueous solutions in pH range from 2.0 to 12.0 in two steps due to the presence of piperazine ring in itsmolecule, possessing two redox centers at the tertiary nitrogen atoms, by an ECE mechanism. Optimal conditions were found for determination of terconazole in 0.1 mol L-1 phosphate buffer pH 7.2. Using differential pulse voltammetry, the lowest detection limit of 0.40 mu mol L-1 and excellent repeatability (RSD 1.1%) were achieved on O-terminated BDD when in-situ anodic activation was used prior to each scan. This is beneficial in comparison with GCE and PGE; their necessity of ex-situ polishing worsens the signal repeatability (RSD similar to 4%) and detection limits reaching 0.50 mu mol L-1 and 1.23 mu mol L-1, respectively.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10406 - Analytical chemistry

Projekt

<a href="/cs/project/GA18-01710S" target="_blank" >GA18-01710S: Skupinové interakce azolových pesticidů a jejich efekt na esenciální enzymy</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2020

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Electroanalytical Chemistry

ISSN

1572-6657

e-ISSN

—

Svazek periodika

863

Číslo periodika v rámci svazku

April

Stát vydavatele periodika

CH - Švýcarská konfederace

Počet stran výsledku

10

Strana od-do

114054

Kód UT WoS článku

000525909600012

EID výsledku v databázi Scopus

2-s2.0-85081932491