Lidocaine adsorption to ethylene-vinyl acetate infusion bags decreases its availability in del Nido cardioplegia solution

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F20%3A10411185" target="_blank" >RIV/00216208:11310/20:10411185 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00064203:_____/20:10411185

Výsledek na webu

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=jT7f_svm01" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=jT7f_svm01</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s00706-020-02602-9" target="_blank" >10.1007/s00706-020-02602-9</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Lidocaine adsorption to ethylene-vinyl acetate infusion bags decreases its availability in del Nido cardioplegia solution

Popis výsledku v původním jazyce

Del Nido cardioplegia solution (dNCS) is frequently used in cardiac surgery. As dNCS is often in-house prepared by hospital pharmacies, an appropriate preparation and storage conditions need to be found and validated. In this study, an 8-week (i.e., 56 days) stability test was performed to monitor the effect of several variables on the stability of dNCS manufactured internally at a hospital pharmacy. Six dNCS variants were prepared that differed in the material of container used, i.e., ethylene-vinyl acetate (EVA) infusion bags or glass infusion bottles, magnesium ions source, and the presence or absence of sodium bicarbonate. Each variant was evaluated for its stability while maintaining at 4 degrees C, 22 degrees C, or 50 degrees C. The concentrations of constituents were monitored using HPLC and capillary electrophoresis. It was found that dNCS is stable at 4 degrees C for 8 weeks and that the replacement of magnesium chloride with magnesium sulfate and/or the absence of sodium bicarbonate has no effect on the stability. On the other hand, if dNCS is not refrigerated or maintained at elevated temperature, the lidocaine concentration in the solution stored in EVA bags can be significantly altered by adsorption of lidocaine to infusion bag material (within 25 days, lidocaine concentration decreases as low as to one half of the original value). Therefore, the dNCS stored in EVA bags should be maintained at 4 degrees C to avoid alternation of its pharmacological effect, because when the solution stored in EVA bag is maintained at elevated temperature, the concentration of lidocaine can be significantly changed. Such change influences the pharmacological effect of the solution leads to serious complications and even endangers the health or life of patients. [GRAPHICS] .

Název v anglickém jazyce

Lidocaine adsorption to ethylene-vinyl acetate infusion bags decreases its availability in del Nido cardioplegia solution

Popis výsledku anglicky

Del Nido cardioplegia solution (dNCS) is frequently used in cardiac surgery. As dNCS is often in-house prepared by hospital pharmacies, an appropriate preparation and storage conditions need to be found and validated. In this study, an 8-week (i.e., 56 days) stability test was performed to monitor the effect of several variables on the stability of dNCS manufactured internally at a hospital pharmacy. Six dNCS variants were prepared that differed in the material of container used, i.e., ethylene-vinyl acetate (EVA) infusion bags or glass infusion bottles, magnesium ions source, and the presence or absence of sodium bicarbonate. Each variant was evaluated for its stability while maintaining at 4 degrees C, 22 degrees C, or 50 degrees C. The concentrations of constituents were monitored using HPLC and capillary electrophoresis. It was found that dNCS is stable at 4 degrees C for 8 weeks and that the replacement of magnesium chloride with magnesium sulfate and/or the absence of sodium bicarbonate has no effect on the stability. On the other hand, if dNCS is not refrigerated or maintained at elevated temperature, the lidocaine concentration in the solution stored in EVA bags can be significantly altered by adsorption of lidocaine to infusion bag material (within 25 days, lidocaine concentration decreases as low as to one half of the original value). Therefore, the dNCS stored in EVA bags should be maintained at 4 degrees C to avoid alternation of its pharmacological effect, because when the solution stored in EVA bag is maintained at elevated temperature, the concentration of lidocaine can be significantly changed. Such change influences the pharmacological effect of the solution leads to serious complications and even endangers the health or life of patients. [GRAPHICS] .

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10406 - Analytical chemistry

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2020

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Monatshefte für Chemie - Chemical Monthly

ISSN

0026-9247

e-ISSN

—

Svazek periodika

151

Číslo periodika v rámci svazku

8

Stát vydavatele periodika

AT - Rakouská republika

Počet stran výsledku

7

Strana od-do

1217-1223

Kód UT WoS článku

000533185400001

EID výsledku v databázi Scopus

2-s2.0-85088856249