The Role of Lipid Environment in Ganglioside GM1-Induced Amyloid beta Aggregation
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F20%3A10422951" target="_blank" >RIV/00216208:11310/20:10422951 - isvavai.cz</a>
Výsledek na webu
<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=aMAFXwSgnC" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=aMAFXwSgnC</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3390/membranes10090226" target="_blank" >10.3390/membranes10090226</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
The Role of Lipid Environment in Ganglioside GM1-Induced Amyloid beta Aggregation
Popis výsledku v původním jazyce
Ganglioside GM1 is the most common brain ganglioside enriched in plasma membrane regions known as lipid rafts or membrane microdomains. GM1 participates in many modulatory and communication functions associated with the development, differentiation, and protection of neuronal tissue. It has, however, been demonstrated that GM1 plays a negative role in the pathophysiology of Alzheimer's disease (AD). The two features of AD are the formation of intracellular neurofibrillary bodies and the accumulation of extracellular amyloid beta (A beta). A beta is a peptide characterized by intrinsic conformational flexibility. Depending on its partners, A beta can adopt different spatial arrangements. GM1 has been shown to induce specific changes in the spatial organization of A beta, which lead to enhanced peptide accumulation and deleterious effect especially on neuronal membranes containing clusters of this ganglioside. Changes in GM1 levels and distribution during the development of AD may contribute to the aggravation of the disease.
Název v anglickém jazyce
The Role of Lipid Environment in Ganglioside GM1-Induced Amyloid beta Aggregation
Popis výsledku anglicky
Ganglioside GM1 is the most common brain ganglioside enriched in plasma membrane regions known as lipid rafts or membrane microdomains. GM1 participates in many modulatory and communication functions associated with the development, differentiation, and protection of neuronal tissue. It has, however, been demonstrated that GM1 plays a negative role in the pathophysiology of Alzheimer's disease (AD). The two features of AD are the formation of intracellular neurofibrillary bodies and the accumulation of extracellular amyloid beta (A beta). A beta is a peptide characterized by intrinsic conformational flexibility. Depending on its partners, A beta can adopt different spatial arrangements. GM1 has been shown to induce specific changes in the spatial organization of A beta, which lead to enhanced peptide accumulation and deleterious effect especially on neuronal membranes containing clusters of this ganglioside. Changes in GM1 levels and distribution during the development of AD may contribute to the aggravation of the disease.
Klasifikace
Druh
J<sub>imp</sub> - Článek v periodiku v databázi Web of Science
CEP obor
—
OECD FORD obor
10601 - Cell biology
Návaznosti výsledku
Projekt
—
Návaznosti
S - Specificky vyzkum na vysokych skolach
Ostatní
Rok uplatnění
2020
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
Membranes
ISSN
2077-0375
e-ISSN
—
Svazek periodika
10
Číslo periodika v rámci svazku
9
Stát vydavatele periodika
CH - Švýcarská konfederace
Počet stran výsledku
22
Strana od-do
226
Kód UT WoS článku
000581377300001
EID výsledku v databázi Scopus
2-s2.0-85090395924