Impact of GM(1) on Membrane-Mediated Aggregation/Oligomerization of beta-Amyloid: Unifying View

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388955%3A_____%2F17%3A00478167" target="_blank" >RIV/61388955:_____/17:00478167 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1016/j.bpj.2017.03.009" target="_blank" >http://dx.doi.org/10.1016/j.bpj.2017.03.009</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.bpj.2017.03.009" target="_blank" >10.1016/j.bpj.2017.03.009</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Impact of GM(1) on Membrane-Mediated Aggregation/Oligomerization of beta-Amyloid: Unifying View

Popis výsledku v původním jazyce

In this perspective we summarize current knowledge of the effect of monosialoganglioside GM(1) on the membrane-mediated aggregation of the beta-amyloid (A beta) peptide. GM(1) has been suggested to be actively involved in the development of Alzheimer's disease due to its ability to seed the aggregation of A beta. However, GM(1) is known to be neuroprotective against A beta-induced toxicity. Here we suggest that the two scenarios are not mutually exclusive but rather complementary, and might depend on the organization of GM(1) in membranes. Improving our understanding of the molecular details behind the role of gangliosides in neurodegenerative amyloidoses might help in developing disease-modifying treatments.

Název v anglickém jazyce

Impact of GM(1) on Membrane-Mediated Aggregation/Oligomerization of beta-Amyloid: Unifying View

Popis výsledku anglicky

In this perspective we summarize current knowledge of the effect of monosialoganglioside GM(1) on the membrane-mediated aggregation of the beta-amyloid (A beta) peptide. GM(1) has been suggested to be actively involved in the development of Alzheimer's disease due to its ability to seed the aggregation of A beta. However, GM(1) is known to be neuroprotective against A beta-induced toxicity. Here we suggest that the two scenarios are not mutually exclusive but rather complementary, and might depend on the organization of GM(1) in membranes. Improving our understanding of the molecular details behind the role of gangliosides in neurodegenerative amyloidoses might help in developing disease-modifying treatments.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10610 - Biophysics

Projekt

<a href="/cs/project/GA17-03160S" target="_blank" >GA17-03160S: Role gangliosidů ve vývoji neurodegenerativních amyloidogenních nemocí: molekulární pohled pomocí pokročilé fluorescenční mikroskopie</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2017

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Biophysical Journal

ISSN

0006-3495

e-ISSN

—

Svazek periodika

113

Číslo periodika v rámci svazku

6

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

6

Strana od-do

1194-1199

Kód UT WoS článku

000411064500007

EID výsledku v databázi Scopus

2-s2.0-85017394553