Boron-doped diamond film and multiple linear regression-based calibration applied to the simultaneous electrochemical determination of paracetamol, phenylephrine hydrochloride, and loratadine in fixed-dose combinations

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F21%3A10426477" target="_blank" >RIV/00216208:11310/21:10426477 - isvavai.cz</a>

Výsledek na webu

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=0SxtLylUeO" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=0SxtLylUeO</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.microc.2020.105831" target="_blank" >10.1016/j.microc.2020.105831</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Boron-doped diamond film and multiple linear regression-based calibration applied to the simultaneous electrochemical determination of paracetamol, phenylephrine hydrochloride, and loratadine in fixed-dose combinations

Popis výsledku v původním jazyce

In this work, we employed multiple linear regression analyses to satisfactorily determine cold symptoms treatment drugs paracetamol, phenylephrine hydrochloride, and loratadine in pharmaceutical formulations with combined dosage and spiked human urine sample. All the drugs are irreversibly oxidized on the boron-doped diamond electrode (BDDE) in diffusion-controlled oxidation processes with well-separated potentials in acidic media. A square-wave voltammetric (SWV) method was developed for their simultaneous determination in 0.1 mol L-1 H2SO4 and simple and multiple linear regression analyses were compared as calibration methods for SWV data. Precision and selectivity were also studied. The high concentration ratio between paracetamol and the other two drugs being minor components in the formulated dosage forms caused interference in their voltammetric responses. An assay based on multiple linear regression equations considering these multiple effects revealed statistically the same results as those obtained by a comparative HPLC-UV method at a 95% confidence level. We demonstrated that multiple linear regression provided adequate recovery for the determination of PAR, PHE, and LOR in spiked human urine sample. The developed SWV method is a very fast, low-cost, and environmentally friendly alternative to the routine simultaneous analysis of PAR, PHE, and LOR performed by HPLC-UV.

Název v anglickém jazyce

Boron-doped diamond film and multiple linear regression-based calibration applied to the simultaneous electrochemical determination of paracetamol, phenylephrine hydrochloride, and loratadine in fixed-dose combinations

Popis výsledku anglicky

In this work, we employed multiple linear regression analyses to satisfactorily determine cold symptoms treatment drugs paracetamol, phenylephrine hydrochloride, and loratadine in pharmaceutical formulations with combined dosage and spiked human urine sample. All the drugs are irreversibly oxidized on the boron-doped diamond electrode (BDDE) in diffusion-controlled oxidation processes with well-separated potentials in acidic media. A square-wave voltammetric (SWV) method was developed for their simultaneous determination in 0.1 mol L-1 H2SO4 and simple and multiple linear regression analyses were compared as calibration methods for SWV data. Precision and selectivity were also studied. The high concentration ratio between paracetamol and the other two drugs being minor components in the formulated dosage forms caused interference in their voltammetric responses. An assay based on multiple linear regression equations considering these multiple effects revealed statistically the same results as those obtained by a comparative HPLC-UV method at a 95% confidence level. We demonstrated that multiple linear regression provided adequate recovery for the determination of PAR, PHE, and LOR in spiked human urine sample. The developed SWV method is a very fast, low-cost, and environmentally friendly alternative to the routine simultaneous analysis of PAR, PHE, and LOR performed by HPLC-UV.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10406 - Analytical chemistry

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2021

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Microchemical Journal

ISSN

0026-265X

e-ISSN

—

Svazek periodika

162

Číslo periodika v rámci svazku

March

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

8

Strana od-do

105831

Kód UT WoS článku

000612265200018

EID výsledku v databázi Scopus

2-s2.0-85099506004