Voltammetric determination of mesalazine in pharmaceutical preparations and biological samples using boron-doped diamond electrode

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216275%3A25310%2F17%3A39910930" target="_blank" >RIV/00216275:25310/17:39910930 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1007/s11696-017-0135-6" target="_blank" >http://dx.doi.org/10.1007/s11696-017-0135-6</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s11696-017-0135-6" target="_blank" >10.1007/s11696-017-0135-6</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Voltammetric determination of mesalazine in pharmaceutical preparations and biological samples using boron-doped diamond electrode

Popis výsledku v původním jazyce

Voltammetric method for the determination of non-steroidal anti-inflammatory drug mesalazine (5-ASA) is presented for the first time using boron-doped diamond electrode (BDDE). 5-ASA provides one well-developed SWV oxidation peak at about -900 mV (vs. saturated silver/silver chloride reference electrode) on BDDE. Britton-Robinson buffer (pH 7.0) was chosen as an optimal supporting electrolyte for the determination of 5-ASA using square wave voltammetry (SWV). Parameters of SWV were developed and low limit of detection (7.0 9 10-7 mol L-1) was reached. In addition, relative standard deviation of repeated measurements (c5-ASA = 5 9 10-5 mol L-1, RSDM = 2.7%) and relative standard deviation of repeated determinations (RSDD 1.5%) were calculated and confirm obtained good results. Applicability of the proposed method was verified by an analysis of a pharmaceutical preparation and spiked human urine.

Název v anglickém jazyce

Voltammetric determination of mesalazine in pharmaceutical preparations and biological samples using boron-doped diamond electrode

Popis výsledku anglicky

Voltammetric method for the determination of non-steroidal anti-inflammatory drug mesalazine (5-ASA) is presented for the first time using boron-doped diamond electrode (BDDE). 5-ASA provides one well-developed SWV oxidation peak at about -900 mV (vs. saturated silver/silver chloride reference electrode) on BDDE. Britton-Robinson buffer (pH 7.0) was chosen as an optimal supporting electrolyte for the determination of 5-ASA using square wave voltammetry (SWV). Parameters of SWV were developed and low limit of detection (7.0 9 10-7 mol L-1) was reached. In addition, relative standard deviation of repeated measurements (c5-ASA = 5 9 10-5 mol L-1, RSDM = 2.7%) and relative standard deviation of repeated determinations (RSDD 1.5%) were calculated and confirm obtained good results. Applicability of the proposed method was verified by an analysis of a pharmaceutical preparation and spiked human urine.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10406 - Analytical chemistry

Projekt

—

Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2017

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Chemical Papers

ISSN

0366-6352

e-ISSN

—

Svazek periodika

71

Číslo periodika v rámci svazku

8

Stát vydavatele periodika

DE - Spolková republika Německo

Počet stran výsledku

9

Strana od-do

1419-1427

Kód UT WoS článku

000405694900005

EID výsledku v databázi Scopus

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