Abacavir: comparison of oxidation mechanisms

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F21%3A10442136" target="_blank" >RIV/00216208:11310/21:10442136 - isvavai.cz</a>

Výsledek na webu

<a href="http://web.natur.cuni.cz/analchem/isc/isc17.pdf" target="_blank" >http://web.natur.cuni.cz/analchem/isc/isc17.pdf</a>

DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Abacavir: comparison of oxidation mechanisms

Popis výsledku v původním jazyce

During forced degradation studies that are a part of the drug product development, an active substance is exposed to extreme conditions. The effect of humidity, light, pH and oxidation on the active substance is studied. The most common way to study the effect of oxidation is to expose active substance to a 0.1-3.0% solution of hydrogen peroxide. Another possibility is to use radical initiators or metal ions. An alternative method is electrochemical oxidation. The oxidation of an active substance is not only affected by the oxidation agent but also depends on the solvent. In this study, the abacavir oxidation in different solvents by different approaches is investigated. The electrochemical oxidation in flow cell was compared with peroxide mediated, radical and metal ions oxidation. Electrochemical oxidation yielded the largest variety of oxidation products from all the tested approaches.

Název v anglickém jazyce

Abacavir: comparison of oxidation mechanisms

Popis výsledku anglicky

During forced degradation studies that are a part of the drug product development, an active substance is exposed to extreme conditions. The effect of humidity, light, pH and oxidation on the active substance is studied. The most common way to study the effect of oxidation is to expose active substance to a 0.1-3.0% solution of hydrogen peroxide. Another possibility is to use radical initiators or metal ions. An alternative method is electrochemical oxidation. The oxidation of an active substance is not only affected by the oxidation agent but also depends on the solvent. In this study, the abacavir oxidation in different solvents by different approaches is investigated. The electrochemical oxidation in flow cell was compared with peroxide mediated, radical and metal ions oxidation. Electrochemical oxidation yielded the largest variety of oxidation products from all the tested approaches.

Druh

D - Stať ve sborníku

CEP obor

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OECD FORD obor

10406 - Analytical chemistry

Projekt

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Návaznosti

S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2021

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název statě ve sborníku

Proceedings of the 17th International Students Conference &quot;Modern Analytical Chemistry&quot;

ISBN

978-80-7444-089-2

ISSN

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e-ISSN

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Počet stran výsledku

7

Strana od-do

73-79

Název nakladatele

Univerzita Karlova, Přírodovědecká fakulta

Místo vydání

Praha

Místo konání akce

Prague

Datum konání akce

16. 9. 2021

Typ akce podle státní příslušnosti

EUR - Evropská akce

Kód UT WoS článku

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