14.11 – Ten-Membered Rings or Larger With One or More Nitrogen Atoms

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F22%3A10437392" target="_blank" >RIV/00216208:11310/22:10437392 - isvavai.cz</a>

Výsledek na webu

<a href="https://doi.org/10.1016/B978-0-12-818655-8.00128-1" target="_blank" >https://doi.org/10.1016/B978-0-12-818655-8.00128-1</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/B978-0-12-818655-8.00128-1" target="_blank" >10.1016/B978-0-12-818655-8.00128-1</a>

Jazyk výsledku

angličtina

Název v původním jazyce

14.11 – Ten-Membered Rings or Larger With One or More Nitrogen Atoms

Popis výsledku v původním jazyce

The chapter covers mainly triaza- and tetraazamacrocyles and, among them, derivatives of cyclen and cyclam. The text presents cyclization procedures, protection strategies and further modifications of the azacycles. The main part is devoted to synthetic modification of the ring secondary amine groups with (coordinating) pendant arms. The azacycles mostly serves as complexation agents (ligands, chelators) and their properties are further modified and tuned through donor atoms present in these pendant arms. Ligands containing another reactive group are often conjugated to biological vectors and these bifunctional ligands are highlighted. The text also covers so-called cross-bridged macrocycles. Properties of the compounds in the solid state are demonstrated on selected examples. Finally, metal binding properties of the azacycles and applications of the complexes as MRI contrast agents, radiopharmaceuticals, luminescence probes and paramagnetic labels are briefly discussed.

Název v anglickém jazyce

14.11 – Ten-Membered Rings or Larger With One or More Nitrogen Atoms

Popis výsledku anglicky

The chapter covers mainly triaza- and tetraazamacrocyles and, among them, derivatives of cyclen and cyclam. The text presents cyclization procedures, protection strategies and further modifications of the azacycles. The main part is devoted to synthetic modification of the ring secondary amine groups with (coordinating) pendant arms. The azacycles mostly serves as complexation agents (ligands, chelators) and their properties are further modified and tuned through donor atoms present in these pendant arms. Ligands containing another reactive group are often conjugated to biological vectors and these bifunctional ligands are highlighted. The text also covers so-called cross-bridged macrocycles. Properties of the compounds in the solid state are demonstrated on selected examples. Finally, metal binding properties of the azacycles and applications of the complexes as MRI contrast agents, radiopharmaceuticals, luminescence probes and paramagnetic labels are briefly discussed.

Druh

C - Kapitola v odborné knize

CEP obor

—

OECD FORD obor

10402 - Inorganic and nuclear chemistry

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2022

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název knihy nebo sborníku

Eight-membered and larger heterocyclic rings and their fused derivates; other seven-membered rings

ISBN

978-0-12-818656-5

Počet stran výsledku

93

Strana od-do

591-683

Počet stran knihy

1002

Název nakladatele

Elsevier

Místo vydání

New York

Kód UT WoS kapitoly

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