Mouse PML protein isoforms and their role in Mouse Polyomavirus infection
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F23%3A10465730" target="_blank" >RIV/00216208:11310/23:10465730 - isvavai.cz</a>
Nalezeny alternativní kódy
RIV/00216208:11310/23:10470047
Výsledek na webu
<a href="https://wbw27.wbworkshops.com/abstracts/" target="_blank" >https://wbw27.wbworkshops.com/abstracts/</a>
DOI - Digital Object Identifier
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Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Mouse PML protein isoforms and their role in Mouse Polyomavirus infection
Popis výsledku v původním jazyce
Promyelocytic leukaemia nuclear bodies (PML NBs) are dynamic, spherical, membrane-less structures composed of the main scaffold PML protein and a variety of stable or transient partner proteins. Apart from many endogenous functions, PML NBs play an important role in antiviral defence, both as direct restriction factors and regulators of the interferon responses. Hence, many viruses developed effective mechanisms to counteract this restriction. This project uses Mouse polyomavirus (MPyV) as a model for studying interactions of PML and viral components. The mouse PML (mPML) protein occurs in three confirmed (mPML1-3) and six predicted (mPMLX1-X6) isoforms. Individual isoforms may affect the composition and functions of PML NBs and mediate antiviral effects.
Název v anglickém jazyce
Mouse PML protein isoforms and their role in Mouse Polyomavirus infection
Popis výsledku anglicky
Promyelocytic leukaemia nuclear bodies (PML NBs) are dynamic, spherical, membrane-less structures composed of the main scaffold PML protein and a variety of stable or transient partner proteins. Apart from many endogenous functions, PML NBs play an important role in antiviral defence, both as direct restriction factors and regulators of the interferon responses. Hence, many viruses developed effective mechanisms to counteract this restriction. This project uses Mouse polyomavirus (MPyV) as a model for studying interactions of PML and viral components. The mouse PML (mPML) protein occurs in three confirmed (mPML1-3) and six predicted (mPMLX1-X6) isoforms. Individual isoforms may affect the composition and functions of PML NBs and mediate antiviral effects.
Klasifikace
Druh
O - Ostatní výsledky
CEP obor
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OECD FORD obor
10607 - Virology
Návaznosti výsledku
Projekt
<a href="/cs/project/LX22NPO5103" target="_blank" >LX22NPO5103: Národní institut virologie a bakteriologie</a><br>
Návaznosti
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Ostatní
Rok uplatnění
2023
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů