Ga(III) pyridinecarboxylate complexes: Potential analogues of the second generation of therapeutic Ga(III) complexes?

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F23%3A10467194" target="_blank" >RIV/00216208:11310/23:10467194 - isvavai.cz</a>

Výsledek na webu

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=p.o238Ifhc" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=p.o238Ifhc</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s00775-023-02012-2" target="_blank" >10.1007/s00775-023-02012-2</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Ga(III) pyridinecarboxylate complexes: Potential analogues of the second generation of therapeutic Ga(III) complexes?

Popis výsledku v původním jazyce

A series of novel Ga(III)-pyridine carboxylates ([Ga(Pic)(3)].H2O (GaPic; HPic = picolinic acid), H3O[Ga(Dpic)(2)].H2O (GaDpic; H(2)Dpic = dipicolinic acid), [Ga(Chel)(H2O)(OH)](2).4H2O (GaChel; H(2)Chel = chelidamic acid) and [Ga(Cldpic)(H2O)(OH)](2) (GaCldpic; H(2)Cldpic = 4-chlorodipicolinic acid)) have been synthesized by simple one-step procedure. Vibrational spectroscopy (mid-IR), elemental analysis, thermogravimetric analysis and X-ray diffraction confirmed complexes molecular structure, inter and intramolecular interactions and their influence to spectral and thermal properties. Moreover, complex species speciation was described in Ga(III)-HPic and Ga(III)-H(2)Dpic systems by potentiometry and (1)H NMR spectroscopy and mononuclear complex species were determined; [Ga(Pic)(2)](+) (log β(021) = 16.23(6)), [Ga(Pic)(3)] (log β(031) = 20.86(2)), [Ga(Dpic)(2)](-) (log β(021) = 15.42(9)) and [Ga(Dpic)(2)(OH)](2-) (log β(-121) = 11.08(4)). To confirm the complexes stability in 1% DMSO (primary solvent for biological testing), timescale (1)H NMR spectra were measured (immediately after dissolution up to 96 h). Antimicrobial activity evaluated by IC50 (0.05 mM) is significant for GaDpic and GaCldpic against difficult to treat and multi-resistant P. aeruginosa. On the other hand, the GaPic complex is most effective against Jurkat, MDA-MB-231 and A2058 cancer cell lines and significantly also decreases the HepG2 cancer cells viability at 75 and 100 μM concentrations in a relatively short time (up to 48 h). In addition, fluorescence measurements have been used to elucidate bovine serum albumin binding activity between ligands, Ga(III) complexes and bovine serum albumin.

Název v anglickém jazyce

Ga(III) pyridinecarboxylate complexes: Potential analogues of the second generation of therapeutic Ga(III) complexes?

Popis výsledku anglicky

A series of novel Ga(III)-pyridine carboxylates ([Ga(Pic)(3)].H2O (GaPic; HPic = picolinic acid), H3O[Ga(Dpic)(2)].H2O (GaDpic; H(2)Dpic = dipicolinic acid), [Ga(Chel)(H2O)(OH)](2).4H2O (GaChel; H(2)Chel = chelidamic acid) and [Ga(Cldpic)(H2O)(OH)](2) (GaCldpic; H(2)Cldpic = 4-chlorodipicolinic acid)) have been synthesized by simple one-step procedure. Vibrational spectroscopy (mid-IR), elemental analysis, thermogravimetric analysis and X-ray diffraction confirmed complexes molecular structure, inter and intramolecular interactions and their influence to spectral and thermal properties. Moreover, complex species speciation was described in Ga(III)-HPic and Ga(III)-H(2)Dpic systems by potentiometry and (1)H NMR spectroscopy and mononuclear complex species were determined; [Ga(Pic)(2)](+) (log β(021) = 16.23(6)), [Ga(Pic)(3)] (log β(031) = 20.86(2)), [Ga(Dpic)(2)](-) (log β(021) = 15.42(9)) and [Ga(Dpic)(2)(OH)](2-) (log β(-121) = 11.08(4)). To confirm the complexes stability in 1% DMSO (primary solvent for biological testing), timescale (1)H NMR spectra were measured (immediately after dissolution up to 96 h). Antimicrobial activity evaluated by IC50 (0.05 mM) is significant for GaDpic and GaCldpic against difficult to treat and multi-resistant P. aeruginosa. On the other hand, the GaPic complex is most effective against Jurkat, MDA-MB-231 and A2058 cancer cell lines and significantly also decreases the HepG2 cancer cells viability at 75 and 100 μM concentrations in a relatively short time (up to 48 h). In addition, fluorescence measurements have been used to elucidate bovine serum albumin binding activity between ligands, Ga(III) complexes and bovine serum albumin.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10402 - Inorganic and nuclear chemistry

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2023

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Biological Inorganic Chemistry

ISSN

0949-8257

e-ISSN

1432-1327

Svazek periodika

28

Číslo periodika v rámci svazku

6

Stát vydavatele periodika

DE - Spolková republika Německo

Počet stran výsledku

21

Strana od-do

591-611

Kód UT WoS článku

001038544600001

EID výsledku v databázi Scopus

2-s2.0-85165928099