Iron level changes in the brain with neurodegenerative disease

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F23%3A10468599" target="_blank" >RIV/00216208:11310/23:10468599 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11110/23:10468599

Výsledek na webu

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=wfgSaH0_eD" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=wfgSaH0_eD</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.brain.2023.100063" target="_blank" >10.1016/j.brain.2023.100063</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Iron level changes in the brain with neurodegenerative disease

Popis výsledku v původním jazyce

Nanosized magnetite inside ferritin may control the progression of neurodegenerative disease (ND) by creating an electronic noise in the neural cells. We discovered that brains with ND have a unique electron paramagnetic resonance (EPR) spectrum. Our measurements showed that the collapse of the broad ferritin maximum contained in the EPR spectra possibly relates to the onset and progression of the ND. Ferritin malfunction triggers the perturbation of iron concentration that either increases or decreases over the normal levels in brain without ND. This supports a conjecture that accumulated iron results in an increased volume of magnetite crystals, whose fluctuated magnetic moments may interfere with the normal function of neural synapses and contribute to the neurodegenerative disease. The mechanism of the iron mobility relates to iron canals in the neural cell&apos;s membrane by which the iron enters and leaves the neural cells. This gate keeper malfunction may relate to a speculation that this is due to the appearance of 2Fe-2S in EPR spectra of brains with ND. Statement of significance: In this manuscript we describe feedback between electronic structure of atoms in the brain, easiness of becoming magnetized in a magnetic field and the ability of the brain to hold the magnetic field on its own in cases of neurodegenerative-diseased and healthy brain. This contribution is novel and significant for a number of reasons, as follows: We revealed that diseased brains have a distinct electronic structure from healthy brains. We identified the easiness of brain samples to become magnetized in a magnetic field and the brains&apos; ability to hold the magnetic field on its own in cases of neurodegenerative-diseased and healthy brains. This paper addresses a new hypothesis, and we consider that it will generate broad that may be of broad interdisciplinary interest and generate further debate.

Název v anglickém jazyce

Iron level changes in the brain with neurodegenerative disease

Popis výsledku anglicky

Nanosized magnetite inside ferritin may control the progression of neurodegenerative disease (ND) by creating an electronic noise in the neural cells. We discovered that brains with ND have a unique electron paramagnetic resonance (EPR) spectrum. Our measurements showed that the collapse of the broad ferritin maximum contained in the EPR spectra possibly relates to the onset and progression of the ND. Ferritin malfunction triggers the perturbation of iron concentration that either increases or decreases over the normal levels in brain without ND. This supports a conjecture that accumulated iron results in an increased volume of magnetite crystals, whose fluctuated magnetic moments may interfere with the normal function of neural synapses and contribute to the neurodegenerative disease. The mechanism of the iron mobility relates to iron canals in the neural cell&apos;s membrane by which the iron enters and leaves the neural cells. This gate keeper malfunction may relate to a speculation that this is due to the appearance of 2Fe-2S in EPR spectra of brains with ND. Statement of significance: In this manuscript we describe feedback between electronic structure of atoms in the brain, easiness of becoming magnetized in a magnetic field and the ability of the brain to hold the magnetic field on its own in cases of neurodegenerative-diseased and healthy brain. This contribution is novel and significant for a number of reasons, as follows: We revealed that diseased brains have a distinct electronic structure from healthy brains. We identified the easiness of brain samples to become magnetized in a magnetic field and the brains&apos; ability to hold the magnetic field on its own in cases of neurodegenerative-diseased and healthy brains. This paper addresses a new hypothesis, and we consider that it will generate broad that may be of broad interdisciplinary interest and generate further debate.

Druh

J_SC - Článek v periodiku v databázi SCOPUS

CEP obor

—

OECD FORD obor

10505 - Geology

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2023

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Brain Multiphysics

ISSN

2666-5220

e-ISSN

2666-5220

Svazek periodika

4

Číslo periodika v rámci svazku

January

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

7

Strana od-do

100063

Kód UT WoS článku

—

EID výsledku v databázi Scopus

2-s2.0-85146467025