Iron-oxide minerals in the human tissues

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378041%3A_____%2F20%3A00560645" target="_blank" >RIV/68378041:_____/20:00560645 - isvavai.cz</a>

Výsledek na webu

<a href="https://link.springer.com/article/10.1007/s10534-020-00232-6" target="_blank" >https://link.springer.com/article/10.1007/s10534-020-00232-6</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s10534-020-00232-6" target="_blank" >10.1007/s10534-020-00232-6</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Iron-oxide minerals in the human tissues

Popis výsledku v původním jazyce

Iron is critically important and highly regulated trace metal in the human body. However, in its free ion form, it is known to be cytotoxic, therefore, it is bound to iron storing protein, ferritin. Ferritin is a key regulator of body iron homeostasis able to form various types of minerals depending on the tissue environment. Each mineral, e.g. magnetite, maghemite, goethite, akaganeite or hematite, present in the ferritin core carry different characteristics possibly affecting cells in the tissue. In specific cases, it can lead to disease development. Widely studied connection with neurodegenerative conditions is widely studied, including Alzheimer disease. Although the exact ferritin structure and its distribution throughout a human body are still not fully known, many studies have attempted to elucidate the mechanisms involved in its regulation and pathogenesis. In this review, we try to summarize the iron uptake into the body. Next, we discuss the known occurrence of ferritin in human tissues. Lastly, we also examine the formation of iron oxides and their involvement in brain functions.

Název v anglickém jazyce

Iron-oxide minerals in the human tissues

Popis výsledku anglicky

Iron is critically important and highly regulated trace metal in the human body. However, in its free ion form, it is known to be cytotoxic, therefore, it is bound to iron storing protein, ferritin. Ferritin is a key regulator of body iron homeostasis able to form various types of minerals depending on the tissue environment. Each mineral, e.g. magnetite, maghemite, goethite, akaganeite or hematite, present in the ferritin core carry different characteristics possibly affecting cells in the tissue. In specific cases, it can lead to disease development. Widely studied connection with neurodegenerative conditions is widely studied, including Alzheimer disease. Although the exact ferritin structure and its distribution throughout a human body are still not fully known, many studies have attempted to elucidate the mechanisms involved in its regulation and pathogenesis. In this review, we try to summarize the iron uptake into the body. Next, we discuss the known occurrence of ferritin in human tissues. Lastly, we also examine the formation of iron oxides and their involvement in brain functions.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30404 - Biomaterials (as related to medical implants, devices, sensors)

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2020

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Biometals

ISSN

0966-0844

e-ISSN

1572-8773

Svazek periodika

33

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

13

Strana od-do

1-13

Kód UT WoS článku

000508702600001

EID výsledku v databázi Scopus

2-s2.0-85078130566