Authentication of two eighteenth century juniper-containing drug remains by HPLC–MS/MS and GC–MSHPLC-MS/MS and GC-MS

Kód výsledku v IS VaVaI

RIV/00216208:11310/23:10471553 - isvavai.cz

Výsledek na webu

https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=mQSS9p54C9

DOI - Digital Object Identifier

10.1007/s00706-023-03096-x

Jazyk výsledku

angličtina

Název v původním jazyce

Authentication of two eighteenth century juniper-containing drug remains by HPLC–MS/MS and GC–MSHPLC-MS/MS and GC-MS

Popis výsledku v původním jazyce

Two historical remains of juniper-containing drugs, dating from the eighteenth century, were analyzed using two separation techniques with mass detection (HPLC-MS/MS and GC-MS). As reference material, replicates of one of these analyzed historical remains, juniper preserve, were prepared according to period recipes. Although the HPLC-MS/MS method was suitable for authenticating the origin of a drug prepared from juniper berries (i.e., juniper preserve), it proved unsuitable for a drug containing only juniper wood. In contrast, GC-MS was able to demonstrate that this drug did indeed contain juniper wood. Thus both studied samples were verified to be juniper-containing drugs. A remarkable stability of some glycosides was observed in the samples analyzed. The presence of viridiflorin was demonstrated for the first time in the juniper plant, and a detailed ESI+-MSn fragmentation of this substance was proposed.

Název v anglickém jazyce

Authentication of two eighteenth century juniper-containing drug remains by HPLC–MS/MS and GC–MSHPLC-MS/MS and GC-MS

Popis výsledku anglicky

Two historical remains of juniper-containing drugs, dating from the eighteenth century, were analyzed using two separation techniques with mass detection (HPLC-MS/MS and GC-MS). As reference material, replicates of one of these analyzed historical remains, juniper preserve, were prepared according to period recipes. Although the HPLC-MS/MS method was suitable for authenticating the origin of a drug prepared from juniper berries (i.e., juniper preserve), it proved unsuitable for a drug containing only juniper wood. In contrast, GC-MS was able to demonstrate that this drug did indeed contain juniper wood. Thus both studied samples were verified to be juniper-containing drugs. A remarkable stability of some glycosides was observed in the samples analyzed. The presence of viridiflorin was demonstrated for the first time in the juniper plant, and a detailed ESI+-MSn fragmentation of this substance was proposed.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10406 - Analytical chemistry

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2023

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Monatshefte für Chemie - Chemical Monthly

ISSN

0026-9247

e-ISSN

1434-4475

Svazek periodika

154

Číslo periodika v rámci svazku

9

Stát vydavatele periodika

AT - Rakouská republika

Počet stran výsledku

10

Strana od-do

977-986

Kód UT WoS článku

001028718100002

EID výsledku v databázi Scopus

2-s2.0-85164465327