STING regulation in polyomavirus infections

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F24%3A10482084" target="_blank" >RIV/00216208:11310/24:10482084 - isvavai.cz</a>

Výsledek na webu

—

DOI - Digital Object Identifier

—

Jazyk výsledku

angličtina

Název v původním jazyce

STING regulation in polyomavirus infections

Popis výsledku v původním jazyce

Stimulator of interferon genes (STING) is an indispensable component of cGAS-STING signalization pathway that plays a key role in the innate immune response to polyomavirus infection. Infection of cells by polyomaviruses resulted in cGAS-STING pathway activation but only moderate interferon beta production was detected indicating possible regulation of the pathway during the infection. STING is a transmembrane protein that predominantly resides in the endoplasmic reticulum (ER). After binding to cGAMP di-nucleotide, STING oligomerizes. Oligomers translocate from ER to trans Golgi reticulum which leads to TBK1 and IRF3 phosphorylation and subsequent interferon-beta production. Later, STING is degraded in proteasomes or autophagosomes.

Název v anglickém jazyce

STING regulation in polyomavirus infections

Popis výsledku anglicky

Stimulator of interferon genes (STING) is an indispensable component of cGAS-STING signalization pathway that plays a key role in the innate immune response to polyomavirus infection. Infection of cells by polyomaviruses resulted in cGAS-STING pathway activation but only moderate interferon beta production was detected indicating possible regulation of the pathway during the infection. STING is a transmembrane protein that predominantly resides in the endoplasmic reticulum (ER). After binding to cGAMP di-nucleotide, STING oligomerizes. Oligomers translocate from ER to trans Golgi reticulum which leads to TBK1 and IRF3 phosphorylation and subsequent interferon-beta production. Later, STING is degraded in proteasomes or autophagosomes.

Druh

O - Ostatní výsledky

CEP obor

—

OECD FORD obor

10607 - Virology

Projekt

<a href="/cs/project/LX22NPO5103" target="_blank" >LX22NPO5103: Národní institut virologie a bakteriologie</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2024

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů