Monocyte cell death induced by sting agonists combines apoptosis, pyroptosis and caspase 8 activation

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F24%3A10486091" target="_blank" >RIV/00216208:11310/24:10486091 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Monocyte cell death induced by sting agonists combines apoptosis, pyroptosis and caspase 8 activation

Popis výsledku v původním jazyce

The cyclic GMP GMP-AMP synthase - stimulator of interferon genes (cGAS cGAS-STING) pathway recognizes double double-stranded DNA in cytoplasm. Activation of the pathway induces secretion of proinflammatory cytokines and subsequently regulates immune mechanisms. The pathway can also be triggered by small molecule molecule-based STING agonists. As such, the cGAS cGAS-STING pathway is of therapeutic interest in the field of viral infections and cancer Importantly, activation of the cGAS cGAS-STING pathway can also lead to cell death regulated 3 We previously demonstarted that STING agonists induce apoptosis in human monocytes, however, the precise processes involved are still under investigation.

Název v anglickém jazyce

Monocyte cell death induced by sting agonists combines apoptosis, pyroptosis and caspase 8 activation

Popis výsledku anglicky

The cyclic GMP GMP-AMP synthase - stimulator of interferon genes (cGAS cGAS-STING) pathway recognizes double double-stranded DNA in cytoplasm. Activation of the pathway induces secretion of proinflammatory cytokines and subsequently regulates immune mechanisms. The pathway can also be triggered by small molecule molecule-based STING agonists. As such, the cGAS cGAS-STING pathway is of therapeutic interest in the field of viral infections and cancer Importantly, activation of the cGAS cGAS-STING pathway can also lead to cell death regulated 3 We previously demonstarted that STING agonists induce apoptosis in human monocytes, however, the precise processes involved are still under investigation.

Druh

O - Ostatní výsledky

CEP obor

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OECD FORD obor

10600 - Biological sciences

Projekt

<a href="/cs/project/LX22NPO5103" target="_blank" >LX22NPO5103: Národní institut virologie a bakteriologie</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2024

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů