STING agonists activate multiple regulated cell death mechanisms in monocytes

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F23%3A10470074" target="_blank" >RIV/00216208:11310/23:10470074 - isvavai.cz</a>

Výsledek na webu

<a href="http://www.ccsss.cz/index.php/ccsss/issue/view/41/" target="_blank" >http://www.ccsss.cz/index.php/ccsss/issue/view/41/</a>

DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

STING agonists activate multiple regulated cell death mechanisms in monocytes

Popis výsledku v původním jazyce

Stimulation of the innate immune responses using agonist of pattern recognition receptors is one of the investigated therapeutic approaches for treatment of chronic diseases, such as cancer or chronic infections. The cyclic-GMP-AMP synthase -stimulator of interferon genes (cGAS-STING) pathway is one potential targetable pathway, as it naturally recognizes double-stranded DNA in the cytoplasm, and in turn triggers secretion of interferons and other proinflammatory cytokines1. The secreted cytokines further mediate various innate immune processes, some of which also induce adaptive immune responses against viral infection or tumors1,2.Importantly, the cGAS-STING pathway can be activated also by small molecules, STING agonists2.

Název v anglickém jazyce

STING agonists activate multiple regulated cell death mechanisms in monocytes

Popis výsledku anglicky

Stimulation of the innate immune responses using agonist of pattern recognition receptors is one of the investigated therapeutic approaches for treatment of chronic diseases, such as cancer or chronic infections. The cyclic-GMP-AMP synthase -stimulator of interferon genes (cGAS-STING) pathway is one potential targetable pathway, as it naturally recognizes double-stranded DNA in the cytoplasm, and in turn triggers secretion of interferons and other proinflammatory cytokines1. The secreted cytokines further mediate various innate immune processes, some of which also induce adaptive immune responses against viral infection or tumors1,2.Importantly, the cGAS-STING pathway can be activated also by small molecules, STING agonists2.

Druh

O - Ostatní výsledky

CEP obor

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OECD FORD obor

30102 - Immunology

Projekt

<a href="/cs/project/LX22NPO5103" target="_blank" >LX22NPO5103: Národní institut virologie a bakteriologie</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2023

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů