Characterization of STING agonist-induced monocyte cell death reveals combination of apoptosis, pyroptosis and caspase 8 activation
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F24%3A10484265" target="_blank" >RIV/00216208:11310/24:10484265 - isvavai.cz</a>
Výsledek na webu
<a href="https://doi.org/10.1002/eji.202470200" target="_blank" >https://doi.org/10.1002/eji.202470200</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/eji.202470200" target="_blank" >10.1002/eji.202470200</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Characterization of STING agonist-induced monocyte cell death reveals combination of apoptosis, pyroptosis and caspase 8 activation
Popis výsledku v původním jazyce
The cyclic-GMP-AMP synthase - stimulator of interferon genes (cGAS-STING) pathway senses double-stranded DNA in cytoplasm, a signal of invading pathogens or cell damage. The activation of the cGAS-STING pathway induces secretion of proinflammatory cytokines by immune cells that in turn modulate antiviral and antitumoral responses. Therefore, synthetic activators of the cGAS-STING pathway, such as STING agonists, are of therapeutic interest.We have recently demonstrated that STING agonists not only trigger cytokine production in peripheral blood mononuclear cells (PBMCs) but also induce cell death of monocytes. Here we investigated the mechanisms of monocyte death in terms of apoptosis, pyroptosis and necroptosis.
Název v anglickém jazyce
Characterization of STING agonist-induced monocyte cell death reveals combination of apoptosis, pyroptosis and caspase 8 activation
Popis výsledku anglicky
The cyclic-GMP-AMP synthase - stimulator of interferon genes (cGAS-STING) pathway senses double-stranded DNA in cytoplasm, a signal of invading pathogens or cell damage. The activation of the cGAS-STING pathway induces secretion of proinflammatory cytokines by immune cells that in turn modulate antiviral and antitumoral responses. Therefore, synthetic activators of the cGAS-STING pathway, such as STING agonists, are of therapeutic interest.We have recently demonstrated that STING agonists not only trigger cytokine production in peripheral blood mononuclear cells (PBMCs) but also induce cell death of monocytes. Here we investigated the mechanisms of monocyte death in terms of apoptosis, pyroptosis and necroptosis.
Klasifikace
Druh
O - Ostatní výsledky
CEP obor
—
OECD FORD obor
30102 - Immunology
Návaznosti výsledku
Projekt
<a href="/cs/project/LX22NPO5103" target="_blank" >LX22NPO5103: Národní institut virologie a bakteriologie</a><br>
Návaznosti
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Ostatní
Rok uplatnění
2024
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů