STING agonist-induced CD14+ monocyte depletion involves multiple regulated cell death mechanisms

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388963%3A_____%2F23%3A00582968" target="_blank" >RIV/61388963:_____/23:00582968 - isvavai.cz</a>

Výsledek na webu

<a href="http://www.ccsss.cz/index.php/ccsss/issue/view/38" target="_blank" >http://www.ccsss.cz/index.php/ccsss/issue/view/38</a>

DOI - Digital Object Identifier

—

Jazyk výsledku

angličtina

Název v původním jazyce

STING agonist-induced CD14+ monocyte depletion involves multiple regulated cell death mechanisms

Popis výsledku v původním jazyce

The immune cells respond to the double-stranded DNA (dsDNA) or cyclic dinucleotide (CDN)-mediated stimulation of the cyclic-GMP-AMP synthase – stimulator of interferon genes (cGAS-STING) pathway by secretion of type I interferons (IFNs) and proinflammatory cytokines. STING agonists also cause a complete depletion of CD14+ monocytes in peripheral blood mononuclear cells (PBMCs). We investigate the cell death mechanisms induced by the cGAS-STING pathway activation focusing on the combination of pyroptosis, apoptosis and necroptosis, so called PANoptosis, demonstrating that CD14+ monocyte cell death could further mediate activation of secondary immune processes including the adaptive immune mechanisms.

Název v anglickém jazyce

STING agonist-induced CD14+ monocyte depletion involves multiple regulated cell death mechanisms

Popis výsledku anglicky

The immune cells respond to the double-stranded DNA (dsDNA) or cyclic dinucleotide (CDN)-mediated stimulation of the cyclic-GMP-AMP synthase – stimulator of interferon genes (cGAS-STING) pathway by secretion of type I interferons (IFNs) and proinflammatory cytokines. STING agonists also cause a complete depletion of CD14+ monocytes in peripheral blood mononuclear cells (PBMCs). We investigate the cell death mechanisms induced by the cGAS-STING pathway activation focusing on the combination of pyroptosis, apoptosis and necroptosis, so called PANoptosis, demonstrating that CD14+ monocyte cell death could further mediate activation of secondary immune processes including the adaptive immune mechanisms.

Druh

O - Ostatní výsledky

CEP obor

—

OECD FORD obor

10601 - Cell biology

Projekt

<a href="/cs/project/LX22NPO5103" target="_blank" >LX22NPO5103: Národní institut virologie a bakteriologie</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2023

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů