Effect of the ADAR1 signalling pathway on HCV replication
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F24%3A10486126" target="_blank" >RIV/00216208:11310/24:10486126 - isvavai.cz</a>
Nalezeny alternativní kódy
RIV/00216208:11310/24:10490056
Výsledek na webu
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DOI - Digital Object Identifier
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Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Effect of the ADAR1 signalling pathway on HCV replication
Popis výsledku v původním jazyce
The hepatitis C virus (HCV) is a member of the Flaviviridae family, the genome of which consists of a +RNA molecule. It causes hepatitis C, which infects tens of millions of people worldwide. Although new direct direct-acting antivirals (DAAs) are highly effective in treating hepatitis C, a preventive vaccine against HCV has not yet been developed.This report examines the relationship between hepatitis C virus (HCV) and the double double-stranded RNA editing enzyme adenosine deaminase 1 (ADAR1). As part of the innate immune response, ADAR1 catalyses the conversion of adenosine to inosine, which affects both the stability of the edited double double-stranded RNA helix and the information encoded in the primary sequence of nucleotides.In order to evaluate the impact of ADAR1 on HCV replication, an ADAR1 knockout cell line was generated from Huh7.5 hepatocellular carcinoma cells. The findings of preliminary experiments examining HCV replication in the Huh7.5 ADAR1 KO cell line will be presented.
Název v anglickém jazyce
Effect of the ADAR1 signalling pathway on HCV replication
Popis výsledku anglicky
The hepatitis C virus (HCV) is a member of the Flaviviridae family, the genome of which consists of a +RNA molecule. It causes hepatitis C, which infects tens of millions of people worldwide. Although new direct direct-acting antivirals (DAAs) are highly effective in treating hepatitis C, a preventive vaccine against HCV has not yet been developed.This report examines the relationship between hepatitis C virus (HCV) and the double double-stranded RNA editing enzyme adenosine deaminase 1 (ADAR1). As part of the innate immune response, ADAR1 catalyses the conversion of adenosine to inosine, which affects both the stability of the edited double double-stranded RNA helix and the information encoded in the primary sequence of nucleotides.In order to evaluate the impact of ADAR1 on HCV replication, an ADAR1 knockout cell line was generated from Huh7.5 hepatocellular carcinoma cells. The findings of preliminary experiments examining HCV replication in the Huh7.5 ADAR1 KO cell line will be presented.
Klasifikace
Druh
O - Ostatní výsledky
CEP obor
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OECD FORD obor
10600 - Biological sciences
Návaznosti výsledku
Projekt
<a href="/cs/project/LX22NPO5103" target="_blank" >LX22NPO5103: Národní institut virologie a bakteriologie</a><br>
Návaznosti
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Ostatní
Rok uplatnění
2024
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů