Jagged-mediated development and disease: Mechanistic insights and therapeutic implications for Alagille syndrome

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F24%3A10487183" target="_blank" >RIV/00216208:11310/24:10487183 - isvavai.cz</a>

Výsledek na webu

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=P1bFhwZ0M-" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=P1bFhwZ0M-</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.ceb.2023.102302" target="_blank" >10.1016/j.ceb.2023.102302</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Jagged-mediated development and disease: Mechanistic insights and therapeutic implications for Alagille syndrome

Popis výsledku v původním jazyce

Notch signaling controls multiple aspects of embryonic development and adult homeostasis. Alagille syndrome is usually caused by a single mutation in the jagged canonical Notch ligand 1 (JAG1), and manifests with liver disease and cardiovascular symptoms that are a direct consequence of JAG1 haploinsufficiency. Recent insights into Jag1/Notch-controlled developmental and homeostatic processes explain how pathology develops in the hepatic and cardiovascular systems and, together with recent elucidation of mechanisms modulating liver regeneration, provide a basis for therapeutic efforts. Importantly, disease presentation can be regulated by genetic modifiers, that may also be therapeutically leverageable. Here, we summarize recent insights into how Jag1 controls processes of relevance to Alagille syndrome, focused on Jag1/ Notch functions in hepatic and cardiovascular development and homeostasis.

Název v anglickém jazyce

Jagged-mediated development and disease: Mechanistic insights and therapeutic implications for Alagille syndrome

Popis výsledku anglicky

Notch signaling controls multiple aspects of embryonic development and adult homeostasis. Alagille syndrome is usually caused by a single mutation in the jagged canonical Notch ligand 1 (JAG1), and manifests with liver disease and cardiovascular symptoms that are a direct consequence of JAG1 haploinsufficiency. Recent insights into Jag1/Notch-controlled developmental and homeostatic processes explain how pathology develops in the hepatic and cardiovascular systems and, together with recent elucidation of mechanisms modulating liver regeneration, provide a basis for therapeutic efforts. Importantly, disease presentation can be regulated by genetic modifiers, that may also be therapeutically leverageable. Here, we summarize recent insights into how Jag1 controls processes of relevance to Alagille syndrome, focused on Jag1/ Notch functions in hepatic and cardiovascular development and homeostasis.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10605 - Developmental biology

Projekt

<a href="/cs/project/EH22_010%2F0002902" target="_blank" >EH22_010/0002902: MSCA Fellowships CZ - UK</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2024

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Current Opinion in Cell Biology

ISSN

0955-0674

e-ISSN

1879-0410

Svazek periodika

86

Číslo periodika v rámci svazku

únor

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

8

Strana od-do

102302

Kód UT WoS článku

001154778900001

EID výsledku v databázi Scopus

2-s2.0-85182188559