Boron-doped diamond electrodes: examining the effect of doping level on the degradation of pharmaceuticals

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F24%3A10493031" target="_blank" >RIV/00216208:11310/24:10493031 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/68378271:_____/24:00597678

Výsledek na webu

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=~GyZtNhc3P" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=~GyZtNhc3P</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s00706-024-03233-0" target="_blank" >10.1007/s00706-024-03233-0</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Boron-doped diamond electrodes: examining the effect of doping level on the degradation of pharmaceuticals

Popis výsledku v původním jazyce

The effect of the boron content doped in the diamond electrode on the oxidative degradation behaviour of the active pharmaceutical ingredient abacavir was investigated. The characteristics of five working boron-doped diamond electrodes, differing in a B/C doping ratio of 500 ppm, 1000 ppm, 2000 ppm, 4000 ppm, and 8000 ppm, were studied. The oxidative degradation of the substance abacavir was studied in a batch cell. The degradation took place under potentiostatic electrolysis at potentials from +0.6 V to +3.7 V. The boron level has a significant effect on the oxidative degradation of the substance at potentials greater than +2.0 V only. Liquid chromatography coupled with mass spectrometry was employed to verify the generation of two primary degradation by-products, namely OP1 (m/z = 319.20) and OP2 (m/z = 247.19). The relative amounts of these degradation products showed variability depending on the diamond electrode used, which was conditioned by different B/C ratios.

Název v anglickém jazyce

Boron-doped diamond electrodes: examining the effect of doping level on the degradation of pharmaceuticals

Popis výsledku anglicky

The effect of the boron content doped in the diamond electrode on the oxidative degradation behaviour of the active pharmaceutical ingredient abacavir was investigated. The characteristics of five working boron-doped diamond electrodes, differing in a B/C doping ratio of 500 ppm, 1000 ppm, 2000 ppm, 4000 ppm, and 8000 ppm, were studied. The oxidative degradation of the substance abacavir was studied in a batch cell. The degradation took place under potentiostatic electrolysis at potentials from +0.6 V to +3.7 V. The boron level has a significant effect on the oxidative degradation of the substance at potentials greater than +2.0 V only. Liquid chromatography coupled with mass spectrometry was employed to verify the generation of two primary degradation by-products, namely OP1 (m/z = 319.20) and OP2 (m/z = 247.19). The relative amounts of these degradation products showed variability depending on the diamond electrode used, which was conditioned by different B/C ratios.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10406 - Analytical chemistry

Projekt

<a href="/cs/project/GA23-05688S" target="_blank" >GA23-05688S: Elektrochemické senzory na bázi nanostrukturovaných a funkcionalizovaných sp2 a sp3 uhlíkových povrchů pro (bio)analytické aplikace</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2024

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Monatshefte für Chemie - Chemical Monthly

ISSN

0026-9247

e-ISSN

1434-4475

Svazek periodika

155

Číslo periodika v rámci svazku

8-9

Stát vydavatele periodika

AT - Rakouská republika

Počet stran výsledku

6

Strana od-do

845-850

Kód UT WoS článku

001275421200004

EID výsledku v databázi Scopus

2-s2.0-85199350490