Comparison of chemical and electrochemical approaches to abacavir oxidative stability testing

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378271%3A_____%2F23%3A00570736" target="_blank" >RIV/68378271:_____/23:00570736 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11310/23:10466231

Výsledek na webu

<a href="https://hdl.handle.net/11104/0342073" target="_blank" >https://hdl.handle.net/11104/0342073</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3390/s23052776" target="_blank" >10.3390/s23052776</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Comparison of chemical and electrochemical approaches to abacavir oxidative stability testing

Popis výsledku v původním jazyce

A novel electrochemical approach using two different electrode materials, platinum and boron-doped diamond (BDD), was employed to study the oxidative stability of the drug abacavir. Abacavir samples were subjected to oxidation and subsequently analysed using chromatography with mass detection. The type and amount of degradation products were evaluated, and results were compared with traditional chemical oxidation using 3% hydrogen peroxide. The effect of pH on the rate of degradation and the formation of degradation products were also investigated. In general, both approaches led to the same two degradation products, identified using mass spectrometry, and characterised by 319.20 and m/z 247.19. Similar results were obtained on a large-surface platinum electrode at a potential of +1.15 V and a BDD disc electrode at +4.0 V.

Název v anglickém jazyce

Comparison of chemical and electrochemical approaches to abacavir oxidative stability testing

Popis výsledku anglicky

A novel electrochemical approach using two different electrode materials, platinum and boron-doped diamond (BDD), was employed to study the oxidative stability of the drug abacavir. Abacavir samples were subjected to oxidation and subsequently analysed using chromatography with mass detection. The type and amount of degradation products were evaluated, and results were compared with traditional chemical oxidation using 3% hydrogen peroxide. The effect of pH on the rate of degradation and the formation of degradation products were also investigated. In general, both approaches led to the same two degradation products, identified using mass spectrometry, and characterised by 319.20 and m/z 247.19. Similar results were obtained on a large-surface platinum electrode at a potential of +1.15 V and a BDD disc electrode at +4.0 V.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10405 - Electrochemistry (dry cells, batteries, fuel cells, corrosion metals, electrolysis)

Projekt

<a href="/cs/project/GA23-05688S" target="_blank" >GA23-05688S: Elektrochemické senzory na bázi nanostrukturovaných a funkcionalizovaných sp2 a sp3 uhlíkových povrchů pro (bio)analytické aplikace</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2023

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Sensors

ISSN

1424-8220

e-ISSN

1424-8220

Svazek periodika

23

Číslo periodika v rámci svazku

5

Stát vydavatele periodika

CH - Švýcarská konfederace

Počet stran výsledku

12

Strana od-do

2776

Kód UT WoS článku

000947657900001

EID výsledku v databázi Scopus

2-s2.0-85149774517