Bone health: Age-related changes in diaphyseal structural properties among European Holocene humans during the last 9000 years
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F25%3A10504850" target="_blank" >RIV/00216208:11310/25:10504850 - isvavai.cz</a>
Výsledek na webu
<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=73dJSisw5r" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=73dJSisw5r</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1126/sciadv.adx7981" target="_blank" >10.1126/sciadv.adx7981</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Bone health: Age-related changes in diaphyseal structural properties among European Holocene humans during the last 9000 years
Popis výsledku v původním jazyce
Age-related deterioration in bone strength among Western humans has been linked with sedentary lifestyles, but the effect remains debatable. We evaluated aging of diaphyseal strength and cortical bone loss in a European Holocene sample of 1881 adult humeri, femora, and tibiae. Diaphyseal aging did not differ between Early and Late Holocene adults, despite their differences in physical activity. Adult diaphyseal aging was accompanied by the disproportionate rate between a faster increase in the medullary area and an absent or marginal increase in the total area. This indicates that subperiosteal apposition did not fully biomechanically compensate for the medullary expansion. Diaphyseal strength remained unchanged through age in female femora and male diaphyses but declined in female humeri and tibiae. We highlight the importance of postnatal growth to compensate for adult medullary expansion. Diaphyseal aging is critical for the upper limbs, as humeri are more sensitive to aging than femora and tibiae.
Název v anglickém jazyce
Bone health: Age-related changes in diaphyseal structural properties among European Holocene humans during the last 9000 years
Popis výsledku anglicky
Age-related deterioration in bone strength among Western humans has been linked with sedentary lifestyles, but the effect remains debatable. We evaluated aging of diaphyseal strength and cortical bone loss in a European Holocene sample of 1881 adult humeri, femora, and tibiae. Diaphyseal aging did not differ between Early and Late Holocene adults, despite their differences in physical activity. Adult diaphyseal aging was accompanied by the disproportionate rate between a faster increase in the medullary area and an absent or marginal increase in the total area. This indicates that subperiosteal apposition did not fully biomechanically compensate for the medullary expansion. Diaphyseal strength remained unchanged through age in female femora and male diaphyses but declined in female humeri and tibiae. We highlight the importance of postnatal growth to compensate for adult medullary expansion. Diaphyseal aging is critical for the upper limbs, as humeri are more sensitive to aging than femora and tibiae.
Klasifikace
Druh
J<sub>imp</sub> - Článek v periodiku v databázi Web of Science
CEP obor
—
OECD FORD obor
10600 - Biological sciences
Návaznosti výsledku
Projekt
<a href="/cs/project/GX21-17092X" target="_blank" >GX21-17092X: Vznik multietnické komplexní společnosti na raně středověké Moravě. Teorie kolektivního jednání a interdisciplinární přístup</a><br>
Návaznosti
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Ostatní
Rok uplatnění
2025
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
Science Advances
ISSN
2375-2548
e-ISSN
2375-2548
Svazek periodika
11
Číslo periodika v rámci svazku
36
Stát vydavatele periodika
US - Spojené státy americké
Počet stran výsledku
12
Strana od-do
eadx7981
Kód UT WoS článku
001566911500012
EID výsledku v databázi Scopus
2-s2.0-105015420733