Intercalation of paracetamol into the hydrotalcite-like host
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11320%2F11%3A10109182" target="_blank" >RIV/00216208:11320/11:10109182 - isvavai.cz</a>
Nalezeny alternativní kódy
RIV/60461373:22310/11:43891830
Výsledek na webu
<a href="http://dx.doi.org/10.1016/j.jssc.2011.10.029" target="_blank" >http://dx.doi.org/10.1016/j.jssc.2011.10.029</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.jssc.2011.10.029" target="_blank" >10.1016/j.jssc.2011.10.029</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Intercalation of paracetamol into the hydrotalcite-like host
Popis výsledku v původním jazyce
Hydrotalcite-like compounds are often used as host structures for intercalation of various anionic species. The product intercalated with the nonionic, water-soluble pharmaceuticals paracetamol, N-(4-hydroxyphenyl)acetamide, was prepared by rehydration of the Mg-Al mixed oxide obtained by calcination of hydrotalcite-like precursor at 500 degrees C. The successful intercalation of paracetamol molecules into the interlayer space was confirmed by powder X-ray diffraction and infrared spectroscopy measurements. Molecular simulations showed that the phenolic hydroxyl groups of paracetamol interact with hydroxide sheets of the host via the hydroxyl groups of the positively charged sites of Al-containing octahedra; the interlayer water molecules are located mostly near the hydroxide sheets. The arrangement of paracetamol molecules in the interlayer is rather disordered and interactions between neighboring molecules cause their tilting towards the hydroxide sheets. Dissolution tests in various
Název v anglickém jazyce
Intercalation of paracetamol into the hydrotalcite-like host
Popis výsledku anglicky
Hydrotalcite-like compounds are often used as host structures for intercalation of various anionic species. The product intercalated with the nonionic, water-soluble pharmaceuticals paracetamol, N-(4-hydroxyphenyl)acetamide, was prepared by rehydration of the Mg-Al mixed oxide obtained by calcination of hydrotalcite-like precursor at 500 degrees C. The successful intercalation of paracetamol molecules into the interlayer space was confirmed by powder X-ray diffraction and infrared spectroscopy measurements. Molecular simulations showed that the phenolic hydroxyl groups of paracetamol interact with hydroxide sheets of the host via the hydroxyl groups of the positively charged sites of Al-containing octahedra; the interlayer water molecules are located mostly near the hydroxide sheets. The arrangement of paracetamol molecules in the interlayer is rather disordered and interactions between neighboring molecules cause their tilting towards the hydroxide sheets. Dissolution tests in various
Klasifikace
Druh
J<sub>x</sub> - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
CEP obor
CF - Fyzikální chemie a teoretická chemie
OECD FORD obor
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Návaznosti výsledku
Projekt
<a href="/cs/project/GAP207%2F10%2F1447" target="_blank" >GAP207/10/1447: Fotoaktivní hybridní materiály</a><br>
Návaznosti
Z - Vyzkumny zamer (s odkazem do CEZ)
Ostatní
Rok uplatnění
2011
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
Journal of Solid State Chemistry
ISSN
0022-4596
e-ISSN
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Svazek periodika
184
Číslo periodika v rámci svazku
12
Stát vydavatele periodika
US - Spojené státy americké
Počet stran výsledku
7
Strana od-do
3329-3335
Kód UT WoS článku
000297662500031
EID výsledku v databázi Scopus
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