Selected Ion Flow-Drift Tube Mass Spectrometry: Quantification of Volatile Compounds in Air and Breath

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11320%2F15%3A10319912" target="_blank" >RIV/00216208:11320/15:10319912 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/61388955:_____/15:00454143

Výsledek na webu

<a href="http://dx.doi.org/10.1021/acs.analchem.5b02994" target="_blank" >http://dx.doi.org/10.1021/acs.analchem.5b02994</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1021/acs.analchem.5b02994" target="_blank" >10.1021/acs.analchem.5b02994</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Selected Ion Flow-Drift Tube Mass Spectrometry: Quantification of Volatile Compounds in Air and Breath

Popis výsledku v původním jazyce

A selected ion flow-drift tube mass spectrometric analytical technique, SIFDT-MS, is described that extends the established selected ion flow tube mass spectrometry, SIFT-MS, by the inclusion of a static but variable E-field along the axis of the flow tube reactor in which the analytical ion molecule chemistry occurs. The ion axial speed is increased in proportion to the reduced field strength E/N (N is the carrier gas number density), and the residence/reaction time, t, which is measured by Hadamard transform multiplexing, is correspondingly reduced. To ensure a proper understanding of the physics and ion chemistry underlying SIFDT-MS, ion diffusive loss to the walls of the flow-drift tube and the mobility of injected H3O+ ions have been studied as a function of E/N. It is seen that the derived diffusion coefficient and mobility of H3O+ ions are consistent with those previously reported. The rate coefficient has been determined at elevated E/N for the association reaction of the H3O+ reagent ions with H2O molecules, which is the first step in the production of H3O+(H2O)(1,2,3) reagent hydrate ions. The production of hydrated analyte ion was also experimentally investigated. The analytical performance of SIFDT-MS is demonstrated by the quantification of acetone and isoprene in exhaled breath. Finally, the essential features of SIFDT-MS and SIFT-MS are compared, notably pointing out that a much lower speed of the flow-drive pump is required for SIFDT-MS, which facilitates the development of smaller cost-effective analytical instruments for real time breath and fluid headspace analyses.

Název v anglickém jazyce

Selected Ion Flow-Drift Tube Mass Spectrometry: Quantification of Volatile Compounds in Air and Breath

Popis výsledku anglicky

A selected ion flow-drift tube mass spectrometric analytical technique, SIFDT-MS, is described that extends the established selected ion flow tube mass spectrometry, SIFT-MS, by the inclusion of a static but variable E-field along the axis of the flow tube reactor in which the analytical ion molecule chemistry occurs. The ion axial speed is increased in proportion to the reduced field strength E/N (N is the carrier gas number density), and the residence/reaction time, t, which is measured by Hadamard transform multiplexing, is correspondingly reduced. To ensure a proper understanding of the physics and ion chemistry underlying SIFDT-MS, ion diffusive loss to the walls of the flow-drift tube and the mobility of injected H3O+ ions have been studied as a function of E/N. It is seen that the derived diffusion coefficient and mobility of H3O+ ions are consistent with those previously reported. The rate coefficient has been determined at elevated E/N for the association reaction of the H3O+ reagent ions with H2O molecules, which is the first step in the production of H3O+(H2O)(1,2,3) reagent hydrate ions. The production of hydrated analyte ion was also experimentally investigated. The analytical performance of SIFDT-MS is demonstrated by the quantification of acetone and isoprene in exhaled breath. Finally, the essential features of SIFDT-MS and SIFT-MS are compared, notably pointing out that a much lower speed of the flow-drive pump is required for SIFDT-MS, which facilitates the development of smaller cost-effective analytical instruments for real time breath and fluid headspace analyses.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

CF - Fyzikální chemie a teoretická chemie

OECD FORD obor

—

Projekt

<a href="/cs/project/GA13-28882S" target="_blank" >GA13-28882S: Excitace, separace a fragmentace iontů v driftovém poli v SIFT-MS pro okamžitou selektivní kvantifikaci stopových plynů</a><br>

Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Analytical Chemistry

ISSN

0003-2700

e-ISSN

—

Svazek periodika

87

Číslo periodika v rámci svazku

24

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

10

Strana od-do

12151-12160

Kód UT WoS článku

000366871500030

EID výsledku v databázi Scopus

2-s2.0-84950140884