Mechanical and biocorrosive properties of magnesium-aluminum alloy scaffold for biomedical applications

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11320%2F19%3A10405472" target="_blank" >RIV/00216208:11320/19:10405472 - isvavai.cz</a>

Výsledek na webu

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=kzB_KQ5bH_" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=kzB_KQ5bH_</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.jmbbm.2019.06.022" target="_blank" >10.1016/j.jmbbm.2019.06.022</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Mechanical and biocorrosive properties of magnesium-aluminum alloy scaffold for biomedical applications

Popis výsledku v původním jazyce

This study investigates the morphology, microstructure, compressive behavior, biocorrosion properties, and cytocompatibility of magnesium (Mg)-aluminum (Al) alloy (AE42) scaffolds for their potential use in biodegradable biomedical applications. Mg alloy scaffolds were successfully synthesized via a camphene-based freeze casting process with precisely controlled heat treatment. The average porosity was approximately 52% and the median pore diameter was similar to 13 mu m. Salient deformation mechanisms were identified using acoustic emission (AE) signals and adaptive sequential k-means (ASK) analysis. Twinning, dislocation slip, strut bending, and collapse were dominant during compressive deformation. Nonetheless, the overall compressive behavior and deformation mechanisms were similar to those of bulk Mg based on ASK analysis. The corrosion potential of the Mg alloy scaffold (-1.44 V) was slightly higher than that of bulk AE42 (-1.60 V), but the corrosion rate of the Mg alloy scaffold was faster than that of bulk AE42 due to the enhanced surface area of the Mg alloy scaffold. As a result of cytocompatibility evaluation following ISO10993-5, the concentration of the Mg alloy scaffold extract reducing cell growth rate to 50% (IC50) was 10.7%, which is higher (less toxic) than 5%, suggesting no severe inflammation by implantation into muscle.

Název v anglickém jazyce

Mechanical and biocorrosive properties of magnesium-aluminum alloy scaffold for biomedical applications

Popis výsledku anglicky

This study investigates the morphology, microstructure, compressive behavior, biocorrosion properties, and cytocompatibility of magnesium (Mg)-aluminum (Al) alloy (AE42) scaffolds for their potential use in biodegradable biomedical applications. Mg alloy scaffolds were successfully synthesized via a camphene-based freeze casting process with precisely controlled heat treatment. The average porosity was approximately 52% and the median pore diameter was similar to 13 mu m. Salient deformation mechanisms were identified using acoustic emission (AE) signals and adaptive sequential k-means (ASK) analysis. Twinning, dislocation slip, strut bending, and collapse were dominant during compressive deformation. Nonetheless, the overall compressive behavior and deformation mechanisms were similar to those of bulk Mg based on ASK analysis. The corrosion potential of the Mg alloy scaffold (-1.44 V) was slightly higher than that of bulk AE42 (-1.60 V), but the corrosion rate of the Mg alloy scaffold was faster than that of bulk AE42 due to the enhanced surface area of the Mg alloy scaffold. As a result of cytocompatibility evaluation following ISO10993-5, the concentration of the Mg alloy scaffold extract reducing cell growth rate to 50% (IC50) was 10.7%, which is higher (less toxic) than 5%, suggesting no severe inflammation by implantation into muscle.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10302 - Condensed matter physics (including formerly solid state physics, supercond.)

Projekt

<a href="/cs/project/GA15-10821S" target="_blank" >GA15-10821S: Velikostní efekt při plastické deformaci materiálů</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2019

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of the Mechanical Behavior of Biomedical Materials

ISSN

1751-6161

e-ISSN

—

Svazek periodika

98

Číslo periodika v rámci svazku

98

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

12

Strana od-do

213-224

Kód UT WoS článku

000483637900025

EID výsledku v databázi Scopus

2-s2.0-85068104198