Evaluation of polycrystalline cerium oxide electrodes for electrochemiluminescent detection of sarcosine

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11320%2F23%3A10475743" target="_blank" >RIV/00216208:11320/23:10475743 - isvavai.cz</a>

Výsledek na webu

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=94H2Ju2rQr" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=94H2Ju2rQr</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.microc.2022.108362" target="_blank" >10.1016/j.microc.2022.108362</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Evaluation of polycrystalline cerium oxide electrodes for electrochemiluminescent detection of sarcosine

Popis výsledku v původním jazyce

Prostate cancer (PCa) is widely spread in male population, especially over 65 years. Currently used medical methods of PCa diagnosis often lead to false-positive results thus new non-invasive methods for PCa detection, such as urine tests for cancer metabolites, are actively studied. Herein, nanostructured polycrystalline cerium oxide thin films (CeO2/GC) prepared by magnetron sputtering on a glassy carbon substrate are tested for electrochemiluminescent (ECL) detection of sar-cosine exploiting the oxidative-reduction mechanism using Ru(bpy)32+ as luminophore. Non-functionalized CeO2/GC electrodes revealed a higher ECL signal stability compared to bare glassy carbon electrodes. Moreover, CeO2/GC electrodes were successfully applied for rapid and sensitive detection of different sarcosine con-centrations ranging from 50 to 5000 mu M. These results open new possibilities for developing sensing platforms for sarcosine detection based on the CeO2/GC working electrode via surface modification and functionalization, aiming to further investigate and improve their sensitivity and selectivity.

Název v anglickém jazyce

Evaluation of polycrystalline cerium oxide electrodes for electrochemiluminescent detection of sarcosine

Popis výsledku anglicky

Prostate cancer (PCa) is widely spread in male population, especially over 65 years. Currently used medical methods of PCa diagnosis often lead to false-positive results thus new non-invasive methods for PCa detection, such as urine tests for cancer metabolites, are actively studied. Herein, nanostructured polycrystalline cerium oxide thin films (CeO2/GC) prepared by magnetron sputtering on a glassy carbon substrate are tested for electrochemiluminescent (ECL) detection of sar-cosine exploiting the oxidative-reduction mechanism using Ru(bpy)32+ as luminophore. Non-functionalized CeO2/GC electrodes revealed a higher ECL signal stability compared to bare glassy carbon electrodes. Moreover, CeO2/GC electrodes were successfully applied for rapid and sensitive detection of different sarcosine con-centrations ranging from 50 to 5000 mu M. These results open new possibilities for developing sensing platforms for sarcosine detection based on the CeO2/GC working electrode via surface modification and functionalization, aiming to further investigate and improve their sensitivity and selectivity.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10305 - Fluids and plasma physics (including surface physics)

Projekt

<a href="/cs/project/LM2018116" target="_blank" >LM2018116: Laboratoř fyziky povrchů - Optická dráha pro výzkum materiálů</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2023

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Microchemical Journal

ISSN

0026-265X

e-ISSN

1095-9149

Svazek periodika

187

Číslo periodika v rámci svazku

Apr

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

6

Strana od-do

108362

Kód UT WoS článku

000961166200001

EID výsledku v databázi Scopus

2-s2.0-85145854972