Artificial magnetosomes: Molecularly restructured SPIONs with enhanced potential for magnetic imaging

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11320%2F24%3A10483552" target="_blank" >RIV/00216208:11320/24:10483552 - isvavai.cz</a>

Výsledek na webu

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=c8ve6cgzc7" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=c8ve6cgzc7</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.mtchem.2024.102206" target="_blank" >10.1016/j.mtchem.2024.102206</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Artificial magnetosomes: Molecularly restructured SPIONs with enhanced potential for magnetic imaging

Popis výsledku v původním jazyce

Magnetosomes represent an elegant example of ultrastable nanomaterials that nature produces by encapsulating magnetic nanoparticles in liposomal sub-compartments of magnetotactic bacteria. Materials chemists continue to strive for ways to mimic the performance of natural systems, but the artificial synthesis of magnetosomes remains unrealized. Here, we report molecular restructuring of the surface of oleic-acid-capped superparamagnetic iron oxide nanoparticles (SPIONs) to produce magnetosomes. Our strategy involves the use of triethylamine as an amphiphilic surfactant that through a combination of ligand exchange and rearrangement mechanisms, facilitates an organic-to-aqueous phase transfer of SPIONs while turning them into magnetosomes. These liposomeencapsulated SPIONs showed dynamic aqueous stability alongside noticeably improved magnetic properties. This improved their performance as contrast agents for magnetic resonance imaging (MRI) and magnetic particle imaging (MPI), the latter revealing a 33.5 % improvement in signal sensitivity over the original SPIONs. The presented strategy is extendable to prepare liposomal dispersions of other biomedically important nanomaterials.

Název v anglickém jazyce

Artificial magnetosomes: Molecularly restructured SPIONs with enhanced potential for magnetic imaging

Popis výsledku anglicky

Magnetosomes represent an elegant example of ultrastable nanomaterials that nature produces by encapsulating magnetic nanoparticles in liposomal sub-compartments of magnetotactic bacteria. Materials chemists continue to strive for ways to mimic the performance of natural systems, but the artificial synthesis of magnetosomes remains unrealized. Here, we report molecular restructuring of the surface of oleic-acid-capped superparamagnetic iron oxide nanoparticles (SPIONs) to produce magnetosomes. Our strategy involves the use of triethylamine as an amphiphilic surfactant that through a combination of ligand exchange and rearrangement mechanisms, facilitates an organic-to-aqueous phase transfer of SPIONs while turning them into magnetosomes. These liposomeencapsulated SPIONs showed dynamic aqueous stability alongside noticeably improved magnetic properties. This improved their performance as contrast agents for magnetic resonance imaging (MRI) and magnetic particle imaging (MPI), the latter revealing a 33.5 % improvement in signal sensitivity over the original SPIONs. The presented strategy is extendable to prepare liposomal dispersions of other biomedically important nanomaterials.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10402 - Inorganic and nuclear chemistry

Projekt

<a href="/cs/project/LM2023065" target="_blank" >LM2023065: Laboratoř pro syntézu a měření materiálů</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2024

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Materials Today Chemistry

ISSN

2468-5194

e-ISSN

—

Svazek periodika

40

Číslo periodika v rámci svazku

září

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

10

Strana od-do

102206

Kód UT WoS článku

001283424900001

EID výsledku v databázi Scopus

2-s2.0-85199534216