The effects of sigma receptor ligand in isolated rat hearts

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F00%3A00003344" target="_blank" >RIV/00216224:14110/00:00003344 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

The effects of sigma receptor ligand in isolated rat hearts

Popis výsledku v původním jazyce

Sigma receptors originally discovered in central nervous system are present in many peripheral tissues, including heart muscle. Our previous experiments with sigma receptor ligands in rat myocytes suggested that these receptors may play a role in modulation of contractility. Sigma receptor binding has been reported to severely impair the regular rhythm in cell cultures probably due to increased [Ca2+]i. The aim of the present study was to prove these effects of highly selective sigma ligand BD737 in thewhole heart. In analogy to the positive inotropic effect in isolated stimulated myocytes, BD737 exerted a slight but significant increase of systolic pressure in perfused hearts. The most typical feature of the effect in both models is a loss of stability. In spontaneously active hearts, the heart rate fluctuates at the rate of 2-3 cycles per minute. This rate is characteristic for IP3 production and [Ca2+]i oscillations. In the present experiments ventricular ectopic beats and periods

Název v anglickém jazyce

The effects of sigma receptor ligand in isolated rat hearts

Popis výsledku anglicky

Sigma receptors originally discovered in central nervous system are present in many peripheral tissues, including heart muscle. Our previous experiments with sigma receptor ligands in rat myocytes suggested that these receptors may play a role in modulation of contractility. Sigma receptor binding has been reported to severely impair the regular rhythm in cell cultures probably due to increased [Ca2+]i. The aim of the present study was to prove these effects of highly selective sigma ligand BD737 in thewhole heart. In analogy to the positive inotropic effect in isolated stimulated myocytes, BD737 exerted a slight but significant increase of systolic pressure in perfused hearts. The most typical feature of the effect in both models is a loss of stability. In spontaneously active hearts, the heart rate fluctuates at the rate of 2-3 cycles per minute. This rate is characteristic for IP3 production and [Ca2+]i oscillations. In the present experiments ventricular ectopic beats and periods

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

ED - Fyziologie

OECD FORD obor

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Projekt

<a href="/cs/project/GA305%2F98%2FP206" target="_blank" >GA305/98/P206: Ovlivnění kontraktility a membránových proudů savčího myokardu prostřednictvím sigma receptorů</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2000

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Physiological Research

ISSN

0862-8408

e-ISSN

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Svazek periodika

49

Číslo periodika v rámci svazku

4

Stát vydavatele periodika

CZ - Česká republika

Počet stran výsledku

1

Strana od-do

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Kód UT WoS článku

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EID výsledku v databázi Scopus

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