Effect of sigma ligand haloperidol in guinea pig heart preparations.

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F02%3A00006468" target="_blank" >RIV/00216224:14110/02:00006468 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Effect of sigma ligand haloperidol in guinea pig heart preparations.

Popis výsledku v původním jazyce

Our previous experiments with sigma receptor ligands in rat myocytes and isolated hearts revealed that these receptors play a role in modulation of contractility. The aim of this study was to examine the effect of sigma ligand haloperidol in the multicellular guinea pig heart preparations. Left atrium and papillary muscle from the right ventricle of 19 adult male guinea pigs were used. Stimulated twitches were recorded in horizontal perfusion baht in the isometrical mode. The effects of haloperidol on the amplitude of twitch and on the restitution of contractility were investigated. In all experiments, marked positive inotropic effect was observed. The mechanical restitution pattern under the effect of sigma receptor ligand was not altered. Thus, the positive inotropic effect of sigma receptor ligand haloperidol was confirmed also in guinea pig atrial and ventricular multicellular heart preparations. According to its effect on the mechanical restitution we can assume that it is mediate

Název v anglickém jazyce

Effect of sigma ligand haloperidol in guinea pig heart preparations.

Popis výsledku anglicky

Our previous experiments with sigma receptor ligands in rat myocytes and isolated hearts revealed that these receptors play a role in modulation of contractility. The aim of this study was to examine the effect of sigma ligand haloperidol in the multicellular guinea pig heart preparations. Left atrium and papillary muscle from the right ventricle of 19 adult male guinea pigs were used. Stimulated twitches were recorded in horizontal perfusion baht in the isometrical mode. The effects of haloperidol on the amplitude of twitch and on the restitution of contractility were investigated. In all experiments, marked positive inotropic effect was observed. The mechanical restitution pattern under the effect of sigma receptor ligand was not altered. Thus, the positive inotropic effect of sigma receptor ligand haloperidol was confirmed also in guinea pig atrial and ventricular multicellular heart preparations. According to its effect on the mechanical restitution we can assume that it is mediate

Druh

D - Stať ve sborníku

CEP obor

ED - Fyziologie

OECD FORD obor

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Projekt

<a href="/cs/project/GA102%2F01%2F1494" target="_blank" >GA102/01/1494: Optické snímání akčních potenciálů a jeho využití v kardiologii</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2002

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název statě ve sborníku

New Frontiers in Basic Cardiovascular Research.

ISBN

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ISSN

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e-ISSN

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Počet stran výsledku

1

Strana od-do

44

Název nakladatele

ÚMFG SAV

Místo vydání

Bratislava

Místo konání akce

4.-7.10.2002, Smolenice, Slovak Republic

Datum konání akce

1. 1. 2002

Typ akce podle státní příslušnosti

EUR - Evropská akce

Kód UT WoS článku

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