Effect of sigma ligand haloperidol in guinea pig heart preparations

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F02%3A00006189" target="_blank" >RIV/00216224:14110/02:00006189 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Effect of sigma ligand haloperidol in guinea pig heart preparations

Popis výsledku v původním jazyce

The effects of sigma ligand haloperidol in the multicellular guinea pig heart preparations were examined. Adult male guinea pigs were used. Left atrium and papillary muscle from right ventricle were examined. The stimulated twiches in horizontal bath were recorded isometrically. Sigma ligand haloperidol (10nM) was administered for 30 minutes. Its effect on the amplitude of contraction and on the mechanical restitution was evaluated. Marked positive inotropic effect (increase in the twitch amplitude ranging from 50 to 90 % for atria and 5 to 45% for ventricles, with maximal effect in the 5th minute of ligand administration for both preparations) has been observed. The mechanical restitution pattern under the effect of sigma receptor ligand is not altered. Thus, the positive inotropic effect of haloperidol was confirmed in guinea pig heart preparations. According to its effect on the mechanical restitution can be assumed that it is mediated via increased cytoplasmatic calcium concentrati

Název v anglickém jazyce

Effect of sigma ligand haloperidol in guinea pig heart preparations

Popis výsledku anglicky

The effects of sigma ligand haloperidol in the multicellular guinea pig heart preparations were examined. Adult male guinea pigs were used. Left atrium and papillary muscle from right ventricle were examined. The stimulated twiches in horizontal bath were recorded isometrically. Sigma ligand haloperidol (10nM) was administered for 30 minutes. Its effect on the amplitude of contraction and on the mechanical restitution was evaluated. Marked positive inotropic effect (increase in the twitch amplitude ranging from 50 to 90 % for atria and 5 to 45% for ventricles, with maximal effect in the 5th minute of ligand administration for both preparations) has been observed. The mechanical restitution pattern under the effect of sigma receptor ligand is not altered. Thus, the positive inotropic effect of haloperidol was confirmed in guinea pig heart preparations. According to its effect on the mechanical restitution can be assumed that it is mediated via increased cytoplasmatic calcium concentrati

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

ED - Fyziologie

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2002

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Molecular and Cellular Cardiology

ISSN

0022-2828

e-ISSN

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Svazek periodika

34

Číslo periodika v rámci svazku

6

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

1

Strana od-do

"A87"

Kód UT WoS článku

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EID výsledku v databázi Scopus

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