Effects of sigma ligand haloperidol on isolated heart.

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F00%3A00003426" target="_blank" >RIV/00216224:14110/00:00003426 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Effects of sigma ligand haloperidol on isolated heart.

Popis výsledku v původním jazyce

It has been suggested that sigma receptors might be responsible for some adverse side effects of the classical neuroleptics, antidepressants, anxiolytics and analgesics. These effects concern nervous tissue as well as some peripheral tissues. Sigma receptors were originally discovered in central nervous system, but they are present also in heart muscle. Our previous experiments with sigma receptor ligands in isolated rat cardiomyocytes suggested that these receptors may play a role in modulation of contractility. Haloperidol is a typical sigma ligand used in everyday clinical practice for treatment of psychoses or severe agitated delirium. Its side effects - cardiac arrhythmias such as torsade de pointes, ventricular fibrillation and other life-threatening complications are well known and have been repeatedly reported. The aim of the present study was to investigate the effects of sigma receptor ligand haloperidol in the whole heart preparation.Previously described arrhythmogenic effec

Název v anglickém jazyce

Effects of sigma ligand haloperidol on isolated heart.

Popis výsledku anglicky

It has been suggested that sigma receptors might be responsible for some adverse side effects of the classical neuroleptics, antidepressants, anxiolytics and analgesics. These effects concern nervous tissue as well as some peripheral tissues. Sigma receptors were originally discovered in central nervous system, but they are present also in heart muscle. Our previous experiments with sigma receptor ligands in isolated rat cardiomyocytes suggested that these receptors may play a role in modulation of contractility. Haloperidol is a typical sigma ligand used in everyday clinical practice for treatment of psychoses or severe agitated delirium. Its side effects - cardiac arrhythmias such as torsade de pointes, ventricular fibrillation and other life-threatening complications are well known and have been repeatedly reported. The aim of the present study was to investigate the effects of sigma receptor ligand haloperidol in the whole heart preparation.Previously described arrhythmogenic effec

Druh

D - Stať ve sborníku

CEP obor

ED - Fyziologie

OECD FORD obor

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Projekt

<a href="/cs/project/GA305%2F98%2FP206" target="_blank" >GA305/98/P206: Ovlivnění kontraktility a membránových proudů savčího myokardu prostřednictvím sigma receptorů</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2000

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název statě ve sborníku

New Frontiers in Basic Cardiovascular Research

ISBN

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ISSN

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e-ISSN

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Počet stran výsledku

2

Strana od-do

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Název nakladatele

Inserm

Místo vydání

Mariánské Lázně

Místo konání akce

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Datum konání akce

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Typ akce podle státní příslušnosti

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Kód UT WoS článku

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