Wavelet Analysis of the Effect of Sigma Ligand Haloperidol on Isolated Rat Heart

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26220%2F01%3APU20112" target="_blank" >RIV/00216305:26220/01:PU20112 - isvavai.cz</a>

Výsledek na webu

—

DOI - Digital Object Identifier

—

Jazyk výsledku

angličtina

Název v původním jazyce

Wavelet Analysis of the Effect of Sigma Ligand Haloperidol on Isolated Rat Heart

Popis výsledku v původním jazyce

Sigma receptors originally discovered in central nervous system are present also in heart muscle. Our previous experiments with sigma receptor ligands in isolated rat cardiomyocytes indicated that these receptors may play a role in modulation of contractility. It has been suggested that sigma receptors might be responsible for some adverse side effects of the classical neuroleptics, antidepressants, anxiolytics and analgesics. These effects concern nervous tissue as well as some peripheral tissues. Halooperidol is a typical sigma ligand used in everyday clinical practice for treatment of psychoses or severe agitated delirium. Its side effects - cardiac arrhythmias and eventually sudden cardiac death - are well known and have been repeatedly reported. To explain possible mechanisms underlying these effects and to get more closely to clinical observations we used a model of isolated heart. Our data were evaluated using the wavelet analysis, an efficient tool in the assessment of short-ti

Název v anglickém jazyce

Wavelet Analysis of the Effect of Sigma Ligand Haloperidol on Isolated Rat Heart

Popis výsledku anglicky

Sigma receptors originally discovered in central nervous system are present also in heart muscle. Our previous experiments with sigma receptor ligands in isolated rat cardiomyocytes indicated that these receptors may play a role in modulation of contractility. It has been suggested that sigma receptors might be responsible for some adverse side effects of the classical neuroleptics, antidepressants, anxiolytics and analgesics. These effects concern nervous tissue as well as some peripheral tissues. Halooperidol is a typical sigma ligand used in everyday clinical practice for treatment of psychoses or severe agitated delirium. Its side effects - cardiac arrhythmias and eventually sudden cardiac death - are well known and have been repeatedly reported. To explain possible mechanisms underlying these effects and to get more closely to clinical observations we used a model of isolated heart. Our data were evaluated using the wavelet analysis, an efficient tool in the assessment of short-ti

Druh

D - Stať ve sborníku

CEP obor

FA - Kardiovaskulární nemoci včetně kardiochirurgie

OECD FORD obor

—

Projekt

<a href="/cs/project/GA102%2F01%2F1494" target="_blank" >GA102/01/1494: Optické snímání akčních potenciálů a jeho využití v kardiologii</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2001

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název statě ve sborníku

Medicon 2001, iX Mediterranean Conference on Medical and BIological Engineering and Computing

ISBN

—

ISSN

—

e-ISSN

—

Počet stran výsledku

4

Strana od-do

418-421

Název nakladatele

International Federation for MEdical and Biological Engineering

Místo vydání

Pula, Chorvatsko

Místo konání akce

Pula, Croatia

Datum konání akce

12. 6. 2001

Typ akce podle státní příslušnosti

WRD - Celosvětová akce

Kód UT WoS článku

—