IgA deficincy in Czech healthy individuals and selected patient groups

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F00%3A00003660" target="_blank" >RIV/00216224:14110/00:00003660 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

IgA deficiency in Czech healthy individuals and selected patient groups

Popis výsledku v původním jazyce

Background: Selective IgA deficiency (IgAD) is the most common immunoglobulin deficiency with a variety of clinical manifestations. The frequency of IgAD differs depending on ethnic origin and clinical symptoms of investigated persons. Methods: The prevalence of IgAD (serum IgA level &lt; 0.05 g/l) was determined in 5310 Czech blood donors, 10 326 patients underwent immunological investigation, and in 246 first degree -relatives of IgA deficient and common variable immunodeficiency (CVID) patients. Results: Selective IgA deficiency was detected in 13 (1: 408; 0.24%) of the blood donors. The prevalence of IgAD was increased both in children (48/3113; 1.5%) and adults (33/3824; 0.9%) referred for frequent respiratory tract infections (in both cases P&lt;0.001) compared to the healthy population. The frequency of IgAD was 12/189 (6%) in first degree relatives of IgAD patients, and 9/57 (16%) in relatives of CVID patients, with the highest frequency observed in children of CVID patients.

Název v anglickém jazyce

IgA deficiency in Czech healthy individuals and selected patient groups

Popis výsledku anglicky

Background: Selective IgA deficiency (IgAD) is the most common immunoglobulin deficiency with a variety of clinical manifestations. The frequency of IgAD differs depending on ethnic origin and clinical symptoms of investigated persons. Methods: The prevalence of IgAD (serum IgA level &lt; 0.05 g/l) was determined in 5310 Czech blood donors, 10 326 patients underwent immunological investigation, and in 246 first degree -relatives of IgA deficient and common variable immunodeficiency (CVID) patients. Results: Selective IgA deficiency was detected in 13 (1: 408; 0.24%) of the blood donors. The prevalence of IgAD was increased both in children (48/3113; 1.5%) and adults (33/3824; 0.9%) referred for frequent respiratory tract infections (in both cases P&lt;0.001) compared to the healthy population. The frequency of IgAD was 12/189 (6%) in first degree relatives of IgAD patients, and 9/57 (16%) in relatives of CVID patients, with the highest frequency observed in children of CVID patients.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

EC - Imunologie

OECD FORD obor

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Projekt

<a href="/cs/project/NI4703" target="_blank" >NI4703: Poruchy imunoregulace u nemocných s humorálními imunodeficity</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2000

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Int Arch Allergy Immunol

ISSN

1018-2438

e-ISSN

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Svazek periodika

123

Číslo periodika v rámci svazku

2

Stát vydavatele periodika

CH - Švýcarská konfederace

Počet stran výsledku

4

Strana od-do

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Kód UT WoS článku

000165180100011

EID výsledku v databázi Scopus

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