An association of BMI with and A(-6)G, M235T and T174M polymorphisms in angiotensinogen gene in essential hypertension

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F02%3A00005721" target="_blank" >RIV/00216224:14110/02:00005721 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

An association of BMI with and A(-6)G, M235T and T174M polymorphisms in angiotensinogen gene in essential hypertension

Popis výsledku v původním jazyce

The aim of the study was to assess the existence of possible associations among frequent polymorphism in angiotensinogen gene and some risk factors for essential hypertension, especially BMI and smoking. 192 control subjects (age 45.87+/-3.0) and 206 patients with the essential hypertension (age 48.71+/- 8.42) were compared at three angiotensinogen gene polymorphisms considering BMI and smoking status. No significant differences in genotype and/or allelic distribution for either A (-6) G ATG or M235T orT174M polymorphisms between the hypertensive and control groups were proved. Significantly more hypertensives than control persons with BMI above 25 kg/m2 were observed (Pcorr=0.009), independently on sex distribution. 44.6% of smokers in control groupvs. 46.0% of smokers in hypertensive groups were found. No significant difference in concurrence of BMI above 25 kg/m2 and positive smoking status between control and hypertensive subjects was found. Statistically significant differences

Název v anglickém jazyce

An association of BMI with and A(-6)G, M235T and T174M polymorphisms in angiotensinogen gene in essential hypertension

Popis výsledku anglicky

The aim of the study was to assess the existence of possible associations among frequent polymorphism in angiotensinogen gene and some risk factors for essential hypertension, especially BMI and smoking. 192 control subjects (age 45.87+/-3.0) and 206 patients with the essential hypertension (age 48.71+/- 8.42) were compared at three angiotensinogen gene polymorphisms considering BMI and smoking status. No significant differences in genotype and/or allelic distribution for either A (-6) G ATG or M235T orT174M polymorphisms between the hypertensive and control groups were proved. Significantly more hypertensives than control persons with BMI above 25 kg/m2 were observed (Pcorr=0.009), independently on sex distribution. 44.6% of smokers in control groupvs. 46.0% of smokers in hypertensive groups were found. No significant difference in concurrence of BMI above 25 kg/m2 and positive smoking status between control and hypertensive subjects was found. Statistically significant differences

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FA - Kardiovaskulární nemoci včetně kardiochirurgie

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2002

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Human Hypertension

ISSN

0950-9240/02

e-ISSN

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Svazek periodika

2002

Číslo periodika v rámci svazku

16

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

4

Strana od-do

427-430

Kód UT WoS článku

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EID výsledku v databázi Scopus

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