Gene polymorphisms (G82S,1704G/T, 2184A/G and 2245G/A) in the receptor of advanced glycation end products (RAGE) with plaque psoriasis

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F02%3A00005742" target="_blank" >RIV/00216224:14110/02:00005742 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Gene polymorphisms (G82S,1704G/T, 2184A/G and 2245G/A) in the receptor of advanced glycation end products (RAGE) with plaque psoriasis

Popis výsledku v původním jazyce

Having in mind relations between oxidative stress, psoriasis and common disorders, associations of polymorphisms in gene coding for RAGE with plaque psoriasis considering personal history of diabetes mellitus, cardiovascular disorders, cancer and allergywere investigated.Allele frequencies and genotype combinations of the four polymorphisms in RAGE gene (6p 21.3, G82S, 1704G/T, 2184A/G and 2245A/G) were compared in a case-control study comprising 272 subjects (130 patients with plaque psoriasis and 142healthy control subjects of comparable age and sex distribution). Polymerase chain reaction with subsequent restriction analysis were used for detection of allele variants. No correlations of alleles and/or genotypes of all examined RAGE polymorphism with positive familiar history of psoriasis and/or early onset of psoriasis manifestation (less than 40 years) were found. The G82S, 1704G/T and 2245A/G RAGE polymorphisms were associated neither with plaque psoriasis nor with personal hist

Název v anglickém jazyce

Gene polymorphisms (G82S,1704G/T, 2184A/G and 2245G/A) in the receptor of advanced glycation end products (RAGE) with plaque psoriasis

Popis výsledku anglicky

Having in mind relations between oxidative stress, psoriasis and common disorders, associations of polymorphisms in gene coding for RAGE with plaque psoriasis considering personal history of diabetes mellitus, cardiovascular disorders, cancer and allergywere investigated.Allele frequencies and genotype combinations of the four polymorphisms in RAGE gene (6p 21.3, G82S, 1704G/T, 2184A/G and 2245A/G) were compared in a case-control study comprising 272 subjects (130 patients with plaque psoriasis and 142healthy control subjects of comparable age and sex distribution). Polymerase chain reaction with subsequent restriction analysis were used for detection of allele variants. No correlations of alleles and/or genotypes of all examined RAGE polymorphism with positive familiar history of psoriasis and/or early onset of psoriasis manifestation (less than 40 years) were found. The G82S, 1704G/T and 2245A/G RAGE polymorphisms were associated neither with plaque psoriasis nor with personal hist

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FO - Dermatovenerologie

OECD FORD obor

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Projekt

<a href="/cs/project/VS96097" target="_blank" >VS96097: Molekulární patofyziologie vybraných "civilizačních", multigenně podmíněných chorob</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2002

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Archives of Dermatological Research

ISSN

0340-3696

e-ISSN

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Svazek periodika

294

Číslo periodika v rámci svazku

2

Stát vydavatele periodika

DE - Spolková republika Německo

Počet stran výsledku

4

Strana od-do

127

Kód UT WoS článku

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EID výsledku v databázi Scopus

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