Role of TAT-system in cardiac excitability: investigation in a quantitative model of a ventricular cardiac cell

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F02%3A00007141" target="_blank" >RIV/00216224:14110/02:00007141 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Role of TAT-system in cardiac excitability: investigation in a quantitative model of a ventricular cardiac cell

Popis výsledku v původním jazyce

To explore the effect of the cardiac transverse axial tubular system (TAT-system) on excitability of ventricular cells, we developed a quantitative model incorporating the function of the tubules. The model was based on a modified quantitative description proposed by Luo and Rudy (Circ Res, 1994;74:1071-96). The modifications are summarized in our previous publication (Pásek M. et al. Scripta Medica, 2002;75:179-86). The morphological parameters of the TAT-system were based on the study of Soeller and Cannel (Circ Res, 1999;84:266-75). The time constants of ionic diffusion between the TAT-system and external solution was set to 250 ms for Ca2+ ions and 63 ms for K+ and Na+ ions. The properties of the tubular and peripheral membrane were set according to recently published data. The results of simulations were strongly affected by incorporation of the TAT-system under the conditions of low external [K+]. The model including TAT-system began to produce early after-depolarizations at cons

Název v anglickém jazyce

Role of TAT-system in cardiac excitability: investigation in a quantitative model of a ventricular cardiac cell

Popis výsledku anglicky

To explore the effect of the cardiac transverse axial tubular system (TAT-system) on excitability of ventricular cells, we developed a quantitative model incorporating the function of the tubules. The model was based on a modified quantitative description proposed by Luo and Rudy (Circ Res, 1994;74:1071-96). The modifications are summarized in our previous publication (Pásek M. et al. Scripta Medica, 2002;75:179-86). The morphological parameters of the TAT-system were based on the study of Soeller and Cannel (Circ Res, 1999;84:266-75). The time constants of ionic diffusion between the TAT-system and external solution was set to 250 ms for Ca2+ ions and 63 ms for K+ and Na+ ions. The properties of the tubular and peripheral membrane were set according to recently published data. The results of simulations were strongly affected by incorporation of the TAT-system under the conditions of low external [K+]. The model including TAT-system began to produce early after-depolarizations at cons

Druh

D - Stať ve sborníku

CEP obor

ED - Fyziologie

OECD FORD obor

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Projekt

<a href="/cs/project/GP204%2F02%2FD129" target="_blank" >GP204/02/D129: Kvantitativní analýza vlivu tubulárního systému na elektrickou aktivitu srdečních buněk</a><br>

Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2002

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název statě ve sborníku

New Frontiers in Basic Cardiovascular Research

ISBN

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ISSN

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e-ISSN

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Počet stran výsledku

1

Strana od-do

47

Název nakladatele

Institute of Molecular Philosophy and Genetics, Slovak Academy of Science

Místo vydání

Smolenice

Místo konání akce

Smolenice

Datum konání akce

1. 1. 2002

Typ akce podle státní příslušnosti

EUR - Evropská akce

Kód UT WoS článku

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