Impact of T-tubules on electrical activity of cardiac cells evaluated in a quantitative model

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F03%3A00008681" target="_blank" >RIV/00216224:14110/03:00008681 - isvavai.cz</a>

Výsledek na webu

—

DOI - Digital Object Identifier

—

Jazyk výsledku

angličtina

Název v původním jazyce

Impact of T-tubules on electrical activity of cardiac cells evaluated in a quantitative model

Popis výsledku v původním jazyce

We report here the first quantitative evaluation of the role of the transverse-axial tubular (TAT) system in the electrical activity of cardiac cells. Our approach uses a biophysically-based representation of the TAT-system incorporated into a model of cardiac ventricular cell (Jafri et al., Biophys. J. 1998, 74:1149-68). The model was modified to agree more closely with recent published data. The differential distribution of ion transfer mechanisms in peripheral and tubular membranes was included (e.g.K+ channels; Christé, J. Mol. Cell. Cardiol. 1999, 31:2207-13). Changes of ion concentrations in the TAT-lumen were computed from the total transmembrane ion fluxes and ion exchanges with the pericellular medium. Long term stability of the model was verified at rest and under regular stimulation, the charge conservation principle being respected. The tubular membrane voltage during an action potential was nearly identical with the peripheral membrane voltage, indicating that propagation

Název v anglickém jazyce

Impact of T-tubules on electrical activity of cardiac cells evaluated in a quantitative model

Popis výsledku anglicky

We report here the first quantitative evaluation of the role of the transverse-axial tubular (TAT) system in the electrical activity of cardiac cells. Our approach uses a biophysically-based representation of the TAT-system incorporated into a model of cardiac ventricular cell (Jafri et al., Biophys. J. 1998, 74:1149-68). The model was modified to agree more closely with recent published data. The differential distribution of ion transfer mechanisms in peripheral and tubular membranes was included (e.g.K+ channels; Christé, J. Mol. Cell. Cardiol. 1999, 31:2207-13). Changes of ion concentrations in the TAT-lumen were computed from the total transmembrane ion fluxes and ion exchanges with the pericellular medium. Long term stability of the model was verified at rest and under regular stimulation, the charge conservation principle being respected. The tubular membrane voltage during an action potential was nearly identical with the peripheral membrane voltage, indicating that propagation

Druh

D - Stať ve sborníku

CEP obor

BO - Biofyzika

OECD FORD obor

—

Projekt

<a href="/cs/project/GP204%2F02%2FD129" target="_blank" >GP204/02/D129: Kvantitativní analýza vlivu tubulárního systému na elektrickou aktivitu srdečních buněk</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2003

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název statě ve sborníku

3rd FEPS Congress -abstract book

ISBN

—

ISSN

—

e-ISSN

—

Počet stran výsledku

1

Strana od-do

60-60

Název nakladatele

Adagp, Paris

Místo vydání

Nice (Francie)

Místo konání akce

Nice

Datum konání akce

28. 6. 2003

Typ akce podle státní příslušnosti

EUR - Evropská akce

Kód UT WoS článku

—