Quantitative modelling of effect of transverse-axial tubular system on electrical activity of cardiac cells: development of model.

Kód výsledku v IS VaVaI

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Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Quantitative modelling of effect of transverse-axial tubular system on electrical activity of cardiac cells: development of model.

Popis výsledku v původním jazyce

The transverse-axial tubular system (TAT-system) of cardiac muscle is a structure that allows rapid propagation of excitation into the cell interior. As suggested in many recent experimental works, it could have a significant effect on cardiac cell function induced by the accumulation or the depletion of ions in restricted tubular space. In our previous work [27], the basic properties of TAT-system were formulated and preliminary simulations characterizing its effect on cellular electrical activity realised. In this article, we describe the design of a more complex model of ventricular myocyte based mostly on data from guinea pig. The model integrates the description of electrical activity of surface and tubular membranes with the detailed descriptionof mechanisms controlling the intracellular and tubular ion concentrations.

Název v anglickém jazyce

Quantitative modelling of effect of transverse-axial tubular system on electrical activity of cardiac cells: development of model.

Popis výsledku anglicky

The transverse-axial tubular system (TAT-system) of cardiac muscle is a structure that allows rapid propagation of excitation into the cell interior. As suggested in many recent experimental works, it could have a significant effect on cardiac cell function induced by the accumulation or the depletion of ions in restricted tubular space. In our previous work [27], the basic properties of TAT-system were formulated and preliminary simulations characterizing its effect on cellular electrical activity realised. In this article, we describe the design of a more complex model of ventricular myocyte based mostly on data from guinea pig. The model integrates the description of electrical activity of surface and tubular membranes with the detailed descriptionof mechanisms controlling the intracellular and tubular ion concentrations.

Druh

D - Stať ve sborníku

CEP obor

BO - Biofyzika

OECD FORD obor

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Projekt

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Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2002

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název statě ve sborníku

Inženýrská mechanika 2002.

ISBN

80-214-2109-6

ISSN

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e-ISSN

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Počet stran výsledku

8

Strana od-do

1-8

Název nakladatele

Institute of Mechanics of Solids, UT Brno

Místo vydání

Svratka

Místo konání akce

Svratka [CZ]

Datum konání akce

13. 5. 2002

Typ akce podle státní příslušnosti

EUR - Evropská akce

Kód UT WoS článku

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