Cannabinoids: effects on behaviour and leukocyte phagocytosis

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F02%3A00007827" target="_blank" >RIV/00216224:14110/02:00007827 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Cannabinoids: effects on behaviour and leukocyte phagocytosis

Popis výsledku v původním jazyce

The study shows that both agonistic and antagonistic manipulation with cannabinoid CB1 as well as CB2 receptor caused changes in social behaviour in mice. Mixed CB1,2 agonists produced biphasic effects - stimulation of aggressive behaviour in timid miceat low doses and inhibition of aggressive activities in aggressive mice at high doses. Inhibitory influence on aggressive behaviour in aggressive mice was present also after all tested doses of selective CB1 agonist, was lower after CB2 agonist and was not apparent after administration of CB1 antagonist. Pro-aggressive effects in timid mice were elicited besides CB1,2 agonists also by both, CB1 and CB2 agonist. The effects of cannabinoid receptor ligands on leukocyte phagocytosis resemble those observedin behavioural studies as CB1,2 agonists produced biphasic influence - stimulation and suppression of phagocytic activity at low and high doses, respectively. Such effects were apparent also after administration of selective CB2 agonist

Název v anglickém jazyce

Cannabinoids: effects on behaviour and leukocyte phagocytosis

Popis výsledku anglicky

The study shows that both agonistic and antagonistic manipulation with cannabinoid CB1 as well as CB2 receptor caused changes in social behaviour in mice. Mixed CB1,2 agonists produced biphasic effects - stimulation of aggressive behaviour in timid miceat low doses and inhibition of aggressive activities in aggressive mice at high doses. Inhibitory influence on aggressive behaviour in aggressive mice was present also after all tested doses of selective CB1 agonist, was lower after CB2 agonist and was not apparent after administration of CB1 antagonist. Pro-aggressive effects in timid mice were elicited besides CB1,2 agonists also by both, CB1 and CB2 agonist. The effects of cannabinoid receptor ligands on leukocyte phagocytosis resemble those observedin behavioural studies as CB1,2 agonists produced biphasic influence - stimulation and suppression of phagocytic activity at low and high doses, respectively. Such effects were apparent also after administration of selective CB2 agonist

Druh

D - Stať ve sborníku

CEP obor

FR - Farmakologie a lékárnická chemie

OECD FORD obor

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Projekt

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Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2002

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název statě ve sborníku

Abstracts of Workshop: Psychopharmacology of Cannabis and Ecstasy

ISBN

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ISSN

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e-ISSN

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Počet stran výsledku

3

Strana od-do

30-32

Název nakladatele

LF MU Brno

Místo vydání

Brno

Místo konání akce

April 18 - 21, 2002, Brno, Czech Republic

Datum konání akce

1. 1. 2002

Typ akce podle státní příslušnosti

WRD - Celosvětová akce

Kód UT WoS článku

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