Desensitisation of sigma receptors in guinea pig atria

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F03%3A00008521" target="_blank" >RIV/00216224:14110/03:00008521 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Desensitisation of sigma receptors in guinea pig atria

Popis výsledku v původním jazyce

Previous studies have shown a modulatory effect of sigma receptor activation on cardiac contractility and its desensitisation. These experiments were performed in isolated rat ventricular myocytes. Since the rat myocardium is well known for a number of quite specific properties, this study was aimed at verifying the effects of sigma ligands in guinea pig atria. Isometric contractions were recorded in 19 adult male guinea pigs (stimulated at the rate of 1Hz). After 30-45 minutes of stabilisation haloperidol in 10nM concentration was added to the bath for 30 minutes. Then, a period of 15 min washout and another 30 min period of haloperidol perfusion followed. The changes of amplitude of contraction and of mechanical restitution were investigated. In allcases, marked positive inotropic effect was observed. The mechanical restitution pattern was not altered. This positive inotropic effect was attenuated after the second haloperidol administration which could indicate that sigma receptors

Název v anglickém jazyce

Desensitisation of sigma receptors in guinea pig atria

Popis výsledku anglicky

Previous studies have shown a modulatory effect of sigma receptor activation on cardiac contractility and its desensitisation. These experiments were performed in isolated rat ventricular myocytes. Since the rat myocardium is well known for a number of quite specific properties, this study was aimed at verifying the effects of sigma ligands in guinea pig atria. Isometric contractions were recorded in 19 adult male guinea pigs (stimulated at the rate of 1Hz). After 30-45 minutes of stabilisation haloperidol in 10nM concentration was added to the bath for 30 minutes. Then, a period of 15 min washout and another 30 min period of haloperidol perfusion followed. The changes of amplitude of contraction and of mechanical restitution were investigated. In allcases, marked positive inotropic effect was observed. The mechanical restitution pattern was not altered. This positive inotropic effect was attenuated after the second haloperidol administration which could indicate that sigma receptors

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

ED - Fyziologie

OECD FORD obor

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Projekt

<a href="/cs/project/GA102%2F01%2F1494" target="_blank" >GA102/01/1494: Optické snímání akčních potenciálů a jeho využití v kardiologii</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2003

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Physiological Research

ISSN

0862-8408

e-ISSN

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Svazek periodika

52

Číslo periodika v rámci svazku

3

Stát vydavatele periodika

CZ - Česká republika

Počet stran výsledku

1

Strana od-do

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Kód UT WoS článku

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EID výsledku v databázi Scopus

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