Paroxetine-Induced Conversion of Cytochrome P450 2D6 Phenotype and Occurence of Adverse Effects

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F03%3A00008770" target="_blank" >RIV/00216224:14110/03:00008770 - isvavai.cz</a>

Výsledek na webu

—

DOI - Digital Object Identifier

—

Jazyk výsledku

angličtina

Název v původním jazyce

Paroxetine-Induced Conversion of Cytochrome P450 2D6 Phenotype and Occurence of Adverse Effects

Popis výsledku v původním jazyce

The paper is focused on a comparison of the distribution of side-effects of treatment with paroxetine within a group of 30 patients genotyped ane phenotyped for their CYP2D6 metabolic status.Genotyping procedure showed that the patient group did not include any individual with poor metabolizer (PM) genotype,on the other hand,most patients (24) were classified as PMs by virtue of their phenotype,which suggests that a conversion to the poor metabolic phenotype occured,probably as a consequence of a long-term administration of the strong CYP2D6 inhibitor paroxetine.As to the occurence of common adverse effects,no marked difference between subjects converted into to PM group and those who had no history of such conversion was found.A significantly higher incidence of sexual dysfunction was,nevertheless,recorded in patients with the PM phenotype.

Název v anglickém jazyce

Paroxetine-Induced Conversion of Cytochrome P450 2D6 Phenotype and Occurence of Adverse Effects

Popis výsledku anglicky

The paper is focused on a comparison of the distribution of side-effects of treatment with paroxetine within a group of 30 patients genotyped ane phenotyped for their CYP2D6 metabolic status.Genotyping procedure showed that the patient group did not include any individual with poor metabolizer (PM) genotype,on the other hand,most patients (24) were classified as PMs by virtue of their phenotype,which suggests that a conversion to the poor metabolic phenotype occured,probably as a consequence of a long-term administration of the strong CYP2D6 inhibitor paroxetine.As to the occurence of common adverse effects,no marked difference between subjects converted into to PM group and those who had no history of such conversion was found.A significantly higher incidence of sexual dysfunction was,nevertheless,recorded in patients with the PM phenotype.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FR - Farmakologie a lékárnická chemie

OECD FORD obor

—

Projekt

—

Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2003

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

General Physiology and Biophysics

ISSN

0231-5882

e-ISSN

—

Svazek periodika

22

Číslo periodika v rámci svazku

2

Stát vydavatele periodika

SK - Slovenská republika

Počet stran výsledku

11

Strana od-do

103-113

Kód UT WoS článku

—

EID výsledku v databázi Scopus

—