Pretreatment with cannabinoid receptor agonist and antagonist increases and decreases, respectively, sensitization to methamphetamine stimulation of mouse locomtor behaviour

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F03%3A00008969" target="_blank" >RIV/00216224:14110/03:00008969 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Pretreatment with cannabinoid receptor agonist and antagonist increases and decreases, respectively, sensitization to methamphetamine stimulation of mouse locomtor behaviour

Popis výsledku v původním jazyce

In Experiment 1, psychostimulant methamphetamine and cannabinoid receptor agonist methanandamide were injected 7 days to two groups of mice either at the doses of 2.5 mg/kg/day or 0,5 mg/kg/day. On the day 8 all mice were given a "challenge dose" of methamphetamine 2.5 mg/kg to check a development of the hypothesised sensitization. In Experiment 2, methamphetamine and combined methamphetamine+selective CB1 receptor antagonist AM 251 treatments were injected 7 days to two groups of mice at the doses of either 2.5 mg/kg/day or 5 mg/kg/day. For the same reason as in Experiment 1 "challenge doses" of methamphetamine 2.5 mg/kg were given to all mice on the day 8. In Experiment 1, it has been shown that compared to control animals this procedure elicited inboth methamphetamine and methanandamide pre-treated groups behavioural sensitisation: significant increase in distance run and fast movements and a significant decrease in resting time. Conversely, in Experiment 2, while in the group pre-

Název v anglickém jazyce

Pretreatment with cannabinoid receptor agonist and antagonist increases and decreases, respectively, sensitization to methamphetamine stimulation of mouse locomtor behaviour

Popis výsledku anglicky

In Experiment 1, psychostimulant methamphetamine and cannabinoid receptor agonist methanandamide were injected 7 days to two groups of mice either at the doses of 2.5 mg/kg/day or 0,5 mg/kg/day. On the day 8 all mice were given a "challenge dose" of methamphetamine 2.5 mg/kg to check a development of the hypothesised sensitization. In Experiment 2, methamphetamine and combined methamphetamine+selective CB1 receptor antagonist AM 251 treatments were injected 7 days to two groups of mice at the doses of either 2.5 mg/kg/day or 5 mg/kg/day. For the same reason as in Experiment 1 "challenge doses" of methamphetamine 2.5 mg/kg were given to all mice on the day 8. In Experiment 1, it has been shown that compared to control animals this procedure elicited inboth methamphetamine and methanandamide pre-treated groups behavioural sensitisation: significant increase in distance run and fast movements and a significant decrease in resting time. Conversely, in Experiment 2, while in the group pre-

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FR - Farmakologie a lékárnická chemie

OECD FORD obor

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Projekt

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Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2003

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Behavioural Pharmacology

ISSN

0955-8810

e-ISSN

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Svazek periodika

14

Číslo periodika v rámci svazku

Suppl. 1

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

1

Strana od-do

60-60

Kód UT WoS článku

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EID výsledku v databázi Scopus

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