Inhibition of cannabinoid CB1 receptor attenuates behavioural sensitization to methamphetamine in mice

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F03%3A00008970" target="_blank" >RIV/00216224:14110/03:00008970 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Inhibition of cannabinoid CB1 receptor attenuates behavioural sensitization to methamphetamine in mice

Popis výsledku v původním jazyce

Behavioural sensitization is typically manifested by increased behavioural responses to the drug. In our previous studies we created an original dosage regimen that produced sensitization to methamphetamine effects on locomotor/exploratory behaviour in mice and also cross-sensitization to methamphetamine with the cannabinoid receptor agonist methanandamide. The changes in the behaviour were recorded in the open field of the Actitrack apparatus (Panlab, S. L., Spain). Methamphetamine and combined methamphetamine+AM 251 treatments were injected to the mice at the doses of 2.5 mg/kg and 5 mg/kg, respectively. On the day 8 all mice were given a "challenge dose" of methamphetamine 2.5 mg/kg to check a development of hypothesised sensitization. In the grouppre-treated with methamphetamine only, a significant behavioural sensitization occurred, whereas in the group pre-treated with the combination of methamphetamine and selective CB1 receptor antagonist AM 251 behavioural responses were sign

Název v anglickém jazyce

Inhibition of cannabinoid CB1 receptor attenuates behavioural sensitization to methamphetamine in mice

Popis výsledku anglicky

Behavioural sensitization is typically manifested by increased behavioural responses to the drug. In our previous studies we created an original dosage regimen that produced sensitization to methamphetamine effects on locomotor/exploratory behaviour in mice and also cross-sensitization to methamphetamine with the cannabinoid receptor agonist methanandamide. The changes in the behaviour were recorded in the open field of the Actitrack apparatus (Panlab, S. L., Spain). Methamphetamine and combined methamphetamine+AM 251 treatments were injected to the mice at the doses of 2.5 mg/kg and 5 mg/kg, respectively. On the day 8 all mice were given a "challenge dose" of methamphetamine 2.5 mg/kg to check a development of hypothesised sensitization. In the grouppre-treated with methamphetamine only, a significant behavioural sensitization occurred, whereas in the group pre-treated with the combination of methamphetamine and selective CB1 receptor antagonist AM 251 behavioural responses were sign

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FR - Farmakologie a lékárnická chemie

OECD FORD obor

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Projekt

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Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2003

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

European Neuropsychopharmacology

ISSN

0924-977X

e-ISSN

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Svazek periodika

13

Číslo periodika v rámci svazku

Suppl. 4

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

2

Strana od-do

416-417

Kód UT WoS článku

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EID výsledku v databázi Scopus

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