Vliv ligandů kanabinoidních receptorů na senzitizaci k účinkům metamfetaminu - ovlivnění lokomoční aktivity u potkanů

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14210%2F08%3A00026170" target="_blank" >RIV/00216224:14210/08:00026170 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Impact of cannabinoid receptor ligands on sensitization to methamphetamine effects on rat locomotor behaviour

Popis výsledku v původním jazyce

Investigation in rats brought very resembling results described earlier in mice. However, there were registered at least some interspecies differences in the rat susceptibility to development of sensitization to methamphetamine effects. Comparing to miceit was more demanding to titrate a dose of methamphetamine producing behavioural sensitization. Furthermore we were not able to provoke cross-sensitization by repeated application of cannabinoid CB1 receptor agonist methanandamide and similarly, we didnot demonstrate suppression of the cross-sensitization in rats that were repeatedly given combined pre-treatment with cannabinoid CB1 receptor antagonist AM 251 and methamphetamine. Finally, unlike the mice there was registered an alternative behaviouralchange after repeated methamphetamine treatment instead, the occurrence of stereotypic behaviour (nose rubbing).

Název v anglickém jazyce

Impact of cannabinoid receptor ligands on sensitization to methamphetamine effects on rat locomotor behaviour

Popis výsledku anglicky

Investigation in rats brought very resembling results described earlier in mice. However, there were registered at least some interspecies differences in the rat susceptibility to development of sensitization to methamphetamine effects. Comparing to miceit was more demanding to titrate a dose of methamphetamine producing behavioural sensitization. Furthermore we were not able to provoke cross-sensitization by repeated application of cannabinoid CB1 receptor agonist methanandamide and similarly, we didnot demonstrate suppression of the cross-sensitization in rats that were repeatedly given combined pre-treatment with cannabinoid CB1 receptor antagonist AM 251 and methamphetamine. Finally, unlike the mice there was registered an alternative behaviouralchange after repeated methamphetamine treatment instead, the occurrence of stereotypic behaviour (nose rubbing).

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FR - Farmakologie a lékárnická chemie

OECD FORD obor

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Projekt

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Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2008

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Acta Veterinaria Brno

ISSN

0001-7213

e-ISSN

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Svazek periodika

77

Číslo periodika v rámci svazku

2

Stát vydavatele periodika

CZ - Česká republika

Počet stran výsledku

9

Strana od-do

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Kód UT WoS článku

000257226400005

EID výsledku v databázi Scopus

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